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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 5757645, 6 pages
http://dx.doi.org/10.1155/2016/5757645
Research Article

The Beneficial Effects of Renal Transplantation on Altered Oxidative Status of ESRD Patients

1Department of Nephrology and Transplants, Specialties Hospital, National Occidental Medical Centre, The Mexican Social Security Institute, Guadalajara, 44349 Guadalajara, JAL, Mexico
2Department of Physiology, University Health Sciences Centre, The University of Guadalajara, Guadalajara, 44150 Guadalajara, JAL, Mexico
3Kidney Diseases Medical Research Unit, Specialties Hospital, National Occidental Medical Centre, Mexican Social Security Institute, Guadalajara, 44349 Guadalajara, JAL, Mexico

Received 17 February 2016; Revised 23 May 2016; Accepted 20 June 2016

Academic Editor: Ange Mouithys-Mickalad

Copyright © 2016 José Ignacio Cerrillos-Gutiérrez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Renal transplantation (RT), has been considered the best therapeutic option for end stage renal disease (ESRD). Objective. To determine the effect of RT on the evolution of oxidative DNA status. Methods. Prospective cohort ( receptors of RT); genotoxic damage, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and DNA repair enzyme, human 8-oxoguanine-DNA-N- glycosylase-1 (hOGG1); and antioxidants, superoxide dismutase (SOD) and glutathione peroxidase (GPx), were evaluated. Results. Before RT, 8-OHdG were significantly elevated ( versus 4.73 ± 0.34 ng/mL) compared to healthy controls (), with normalization after 6 months of  ng/mL (). The same phenomenon was observed with hOGG1 enzyme before RT with 2.14 ± 0.36 ng/mL () and decreased significantly at the end of the study to 1.20 ng/mL () but was higher than controls, 0.51 ± 0.07 ng/mL (). Antioxidant SOD was elevated at 24.09 ± 1.6 IU/mL versus healthy controls () before RT; however, 6 months after RT it decreased significantly to 16.9 ± 1.6 IU/mL (), without achieving the levels of healthy controls (). The GPx, before RT, was significantly diminished with 24.09 ± 1.6 IU/mL versus healthy controls (39.0 ± 1.58) (), while, in the final results, levels increased significantly to 30.38 ± 3.16 IU/mL (). Discussion. Patients with ESRD have important oxidative damage before RT. The RT significantly reduces oxidative damage and partially regulates the antioxidant enzymes (SOD and GPx).