Exercise Training Attenuates Upregulation of p47<sup>phox</sup> and p67<sup>phox</sup> in Hearts of Diabetic Rats

<div>Amelioration of cardiomyopathy by exercise training. Hyperglycemia induces overexpression of cytoplasmic subunits of NADH oxidase (<svg height="15.287pt" id="M183" style="vertical-align:-3.1293pt" version="1.1" viewbox="-0.0498162 -12.1577 38.7052 15.287" width="38.7052pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M169 380V459C122 440 66 423 24 416V392C86 384 90 382 90 317V-135C90 -201 81 -207 17 -213V-240H253V-213C176 -207 169 -201 169 -125V6C182 -1 208 -11 238 -12C368 12 487 109 487 260C487 358 421 449 310 449C298 449 279 444 261 433L169 380ZM169 346C196 367 237 389 269 389C341 389 403 329 403 221C403 109 347 37 263 37C228 37 191 53 169 76V346Z" id="g121-110"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="524" vert-adv-y="524"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,6.812,0)"><path d="M456 178V225H360V632H320C217 496 115 347 20 206V178H280V106C280 40 276 34 189 27V0H445V27C364 34 360 39 360 106V178H456ZM280 225H82C149 335 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324 400 307 369C290 337 270 307 251 279L194 367C175 396 180 402 220 409V439H18V409C74 401 87 395 117 349L204 213C173 168 147 130 119 95C78 46 67 38 5 30V0H195V30C144 38 143 47 162 79C181 112 202 149 225 181L297 70C314 43 307 35 264 30V0H482Z" id="g58-118"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="481" vert-adv-y="481"></glyph.data></g></svg> and <svg height="15.287pt" id="M184" style="vertical-align:-3.1293pt" version="1.1" viewbox="-0.0498162 -12.1577 38.7052 15.287" width="38.7052pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M169 380V459C122 440 66 423 24 416V392C86 384 90 382 90 317V-135C90 -201 81 -207 17 -213V-240H253V-213C176 -207 169 -201 169 -125V6C182 -1 208 -11 238 -12C368 12 487 109 487 260C487 358 421 449 310 449C298 449 279 444 261 433L169 380ZM169 346C196 367 237 389 269 389C341 389 403 329 403 221C403 109 347 37 263 37C228 37 191 53 169 76V346Z" 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Overexpression of these subunits exhibits high reactive oxygen species and leads to increased collagen III and hence cardiomyopathy. Exercise training (ExT) mitigates the expression of <svg height="15.287pt" id="M185" style="vertical-align:-3.1293pt" version="1.1" viewbox="-0.0498162 -12.1577 38.7052 15.287" width="38.7052pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M169 380V459C122 440 66 423 24 416V392C86 384 90 382 90 317V-135C90 -201 81 -207 17 -213V-240H253V-213C176 -207 169 -201 169 -125V6C182 -1 208 -11 238 -12C368 12 487 109 487 260C487 358 421 449 310 449C298 449 279 444 261 433L169 380ZM169 346C196 367 237 389 269 389C341 389 403 329 403 221C403 109 347 37 263 37C228 37 191 53 169 76V346Z" id="g121-110"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="524" vert-adv-y="524"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,6.812,0)"><path d="M456 178V225H360V632H320C217 496 115 347 20 206V178H280V106C280 40 276 34 189 27V0H445V27C364 34 360 39 360 106V178H456ZM280 225H82C149 335 214 431 278 520H280V225Z" 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Exercise Training Attenuates Upregulation of p47<sup>phox</sup> and p67<sup>phox</sup> in Hearts of Diabetic Rats 

Oxidative Medicine and Cellular Longevity

Exercise Training Attenuates Upregulation of p47phox and p67phox in Hearts of Diabetic Rats

Figure 5

Exercise Training Attenuates Upregulation of p47^phox and p67^phox in Hearts of Diabetic Rats