Higher Urinary Levels of 8-Hydroxy-2′-deoxyguanosine Are Associated with a Worse RANKL/OPG Ratio in Postmenopausal Women with Osteopenia

Table 3

Simple linear regression analysis for the relationship between urinary level of 8-OHdG and serum levels of RANKL, OPG, and RANKL/OPG ratio in normal, osteopenic, and osteoporotic postmenopausal women.

		Normal BMD	Osteopenia	Osteoporosis
RANKL	(DS)	0.325 (0.389)	0.554 (0.164)	0.018 (0.212)
	Beta	0.188	0.423	0.014
		0.035	0.180	0.001
OPG	(DS)	−0.048 (0.288)	−0.256 (0.175)	−0.093 (0.256)
	Beta	−0.037	−0.196	−0.089
		0.001	0.038	0.004
RANKL/OPG	(DS)	0.368 (0.549)	0.879 (0.262)	0.161 (315)
	Beta	0.160	0.429	0.086
		0.026	0.184	0.007

.
Beta: standardized regression coefficient; : nonstandardized regression coefficient; BMD: bone mass density; OPG: osteoprotegerin; RANKL: receptor activator of nuclear factor kappa-B ligand; 8-OHdG: 8-hydroxy-2′-deoxyguanosine.