Review Article
Hydrogen Sulfide and Cellular Redox Homeostasis
Figure 4
Effect of H2S on intracellular enzymatic and nonenzymatic antioxidant production. H2S activates Nrf2, which translocates to nuclear, binds to ARE, and upregulates enzymatic and nonenzymatic antioxidant production. H2S stimulates NF-κB signaling, which further upregulates the expression of numerous genes including SOD, CAT, and GPx.