TY - JOUR
A2 - Llopis, Juan
AU - Treviño, Samuel
AU - Velázquez-Vázquez, Denisse
AU - Sánchez-Lara, Eduardo
AU - Diaz-Fonseca, Alfonso
AU - Flores-Hernandez, José Ángel
AU - Pérez-Benítez, Aarón
AU - Brambila-Colombres, Eduardo
AU - González-Vergara, Enrique
PY - 2016
DA - 2016/03/28
TI - Metforminium Decavanadate as a Potential Metallopharmaceutical Drug for the Treatment of Diabetes Mellitus
SP - 6058705
VL - 2016
AB - New potential drugs based on vanadium are being developed as possible treatments for diabetes mellitus (DM) and its complications. In this regard, our working group developed metforminium decavanadate (MetfDeca), a compound with hypoglycemic and hypolipidemic properties. MetfDeca was evaluated in models of type 1 and type 2 diabetes mellitus, on male Wistar rats. Alloxan-induction was employed to produce DM1 model, while a hypercaloric-diet was employed to generate DM2 model. Two-month treatments with 3.7 μg (2.5 μM)/300 g/twice a week for DM2 and 7.18 μg (4.8 μM)/300 g/twice a week for DM1 of MetfDeca, respectively, were administered. The resulting pharmacological data showed nontoxicological effects on liver and kidney. At the same time, MetfDeca showed an improvement of carbohydrates and lipids in tissues and serum. MetfDeca treatment was better than the monotherapies with metformin for DM2 and insulin for DM1. Additionally, MetfDeca showed a protective effect on pancreatic beta cells of DM1 rats, suggesting a possible regeneration of these cells, since they recovered their insulin levels. Therefore, MetfDeca could be considered not only as an insulin-mimetic agent, but also as an insulin-enhancing agent. Efforts to elucidate the mechanism of action of this compound are now in progress.
SN - 1942-0900
UR - https://doi.org/10.1155/2016/6058705
DO - 10.1155/2016/6058705
JF - Oxidative Medicine and Cellular Longevity
PB - Hindawi Publishing Corporation
KW -
ER -