Metforminium Decavanadate as a Potential Metallopharmaceutical Drug for the Treatment of Diabetes Mellitus

Table 2

Serum lipids in independent insulin model and insulin-requiring model with pharmacological treatments and MetfDeca.

Metabolite	NC ()	I-I ()	I-I + Metf ()	I-I + MetfDeca ()	I-R ()	I-R + insulin ()	I-R + MetfDeca ()
Total lipids (mg/dL)		▲	↓	↓	▲	▲	▲↓
Triglycerides (mg/dL)		▲	↓	▲	▲	▲	↓
Cholesterol (mg/dL)		▲	▲	↓	▲	▲	▲↓
VLDL-C (mg/dL)		▲		▲	▲	▲↓	↓
LDL-C (mg/dL)		▲	↓	↓		▲	▲
HDL-C (mg/dL)		▼	▲		▲	▲	↓
FFA (mg/dL)		▲	↓	↓	▲	↓	▲↓

The results shown are the average of 20 separate experimental animals ± SEM. ▲ indicates significant difference with values above the control group with normal calorie diet, ▼ indicates significant difference with values below the control group with normal calorie diet, while ↓ indicates significant difference with respect to groups I-I and I-R, one-way ANOVA test with Bonferroni post hoc test.