Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2

Figure 3

Effects of diquat alone or combined with GSPB2 on autophagy levels in antral follicles. Mice were treated with diquat or saline or in combination with GSPB2. The right ovarian sections were used for immunohistological study and granulosa cells were isolated from left ovaries to investigate the changes of autophagy-related gene expression. (a) Immunostaining of ovary sections was detected by using anti-LC3-II. (b) The relative expression levels of autophagy-related genes. Results are expressed as means ± SEM, , and versus diquat alone.

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