Vascular Protective Effect of an Ethanol Extract of Camellia japonica Fruit: Endothelium-Dependent Relaxation of Coronary Artery and Reduction of Smooth Muscle Cell Migration

Figure 3

Characterization of endothelium-dependent relaxations to CJF in porcine coronary artery rings. Rings with endothelium were incubated with either indomethacin (10 μM), N^ω-nitro-L-arginine (L-NA, 10 μM), charybdotoxin (CTX, 100 nM) plus apamin (APA, 100 nM), or the PI3-kinase inhibitors wortmannin (30 nM) for 30 min before the contraction to U46619 and subsequent relaxation to CJF. The relaxation response is expressed as the percentage relaxation of the U46619-induced contraction. Results are shown as means ± SEM (). , , , significant difference versus control.

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