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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 6429812, 9 pages
Research Article

Can Breast Tumors Affect the Oxidative Status of the Surrounding Environment? A Comparative Analysis among Cancerous Breast, Mammary Adjacent Tissue, and Plasma

1Laboratory of Inflammatory Mediators, State University of West Paraná (UNIOESTE), Campus Francisco Beltrão, 85605-010 Francisco Beltrão, PR, Brazil
2School of Medicine, State University of Sao Paulo (USP), 07112-000 São Paulo, SP, Brazil
3School of Medicine, Pontifícia Universidade Católica (PUC), Campus Londrina, 86051-990 Londrina, PR, Brazil
4Laboratory of Physiopathology and Free Radicals, Department of General Pathology, State University of Londrina (UEL), 86051-990 Londrina, PR, Brazil
5University Hospital, Department of Pharmacy, State University of Londrina (UEL), 86051-990 Londrina, PR, Brazil
6Department of Preventive Medicine, Federal University of São Paulo (UNIFESP), 07112-000 São Paulo, SP, Brazil

Received 22 May 2015; Revised 4 August 2015; Accepted 12 August 2015

Academic Editor: Manoj K. Pandey

Copyright © 2016 C. Panis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this paper, we investigated the oxidative profile of breast tumors in comparison with their normal adjacent breast tissue. Our study indicates that breast tumors present enhanced oxidative/nitrosative stress, with concomitant augmented antioxidant capacity when compared to the adjacent normal breast. These data indicate that breast cancers may be responsible for the induction of a prooxidant environment in the mammary gland, in association with enhanced TNF-α and nitric oxide.