The H2S Donor NaHS Changes the Expression Pattern of H2S-Producing Enzymes after Myocardial Infarction
Endogenous H2S protected cardiomyocytes from hypoxia-induced injury. (a and b) Compared with the hypoxia control, CSE siRNA significantly decreased CSE expression and H2S levels in the culture medium, whereas CBS and 3-MST expressions increased; (c) the activity of the three H2S-producing enzymes did not change after CSE siRNA treatment. (d) CSE siRNA exacerbated hypoxia injury, demonstrated by an increase in LDH activity and a decrease in CCK8 values. Numbers inside bars denote the number of animals per group. Values are mean ± SE. and .