Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 6719534, 19 pages
http://dx.doi.org/10.1155/2016/6719534
Review Article

Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results

1Institute of Biopathology and Regenerative Medicine, University of Granada, 18071 Granada, Spain
2Department of Cardiovascular Surgery, Virgen de las Nieves Hospital, 18014 Granada, Spain

Received 22 June 2015; Accepted 12 August 2015

Academic Editor: Sahdeo Prasad

Copyright © 2016 Nuria Mut-Salud et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Halliwell, J. M. C. Gutteridge, and C. E. Cross, “Free radicals, antioxidants, and human disease: where are we now?” The Journal of Laboratory and Clinical Medicine, vol. 119, no. 6, pp. 598–620, 1992. View at Google Scholar · View at Scopus
  2. B. Halliwell and J. M. C. Gutteridge, “The antioxidants of human extracellular fluids,” Archives of Biochemistry and Biophysics, vol. 280, no. 1, pp. 1–8, 1990. View at Publisher · View at Google Scholar · View at Scopus
  3. A. I. Khlebnikov, I. A. Schepetkin, N. G. Domina, L. N. Kirpotina, and M. T. Quinn, “Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems,” Bioorganic and Medicinal Chemistry, vol. 15, no. 4, pp. 1749–1770, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. L. A. Pham-Huy, H. He, and C. Pham-Huy, “Free radicals, antioxidants in disease and health,” International Journal of Biomedical Science, vol. 4, no. 2, pp. 89–96, 2008. View at Google Scholar · View at Scopus
  5. M. Fransen, M. Nordgren, B. Wang, and O. Apanasets, “Role of peroxisomes in ROS/RNS-metabolism: implications for human disease,” Biochimica et Biophysica Acta—Molecular Basis of Disease, vol. 1822, no. 9, pp. 1363–1373, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. F. J. Corpas and J. B. Barroso, “Reactive sulfur species (RSS): possible new players in the oxidative metabolism of plant peroxisomes,” Frontiers in Plant Science, vol. 6, article 116, 2015. View at Publisher · View at Google Scholar
  7. S. Hekimi, J. Lapointe, and Y. Wen, “Taking a ‘good’ look at free radicals in the aging process,” Trends in Cell Biology, vol. 21, no. 10, pp. 569–576, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Kawagishi and T. Finkel, “Unraveling the truth about antioxidants: ROS and disease: finding the right balance,” Nature Medicine, vol. 20, no. 7, pp. 711–713, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Popa-Wagner, S. Mitran, S. Sivanesan, E. Chang, and A.-M. Buga, “ROS and brain diseases: the good, the bad, and the ugly,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 963520, 14 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. B. Zhao, “Natural antioxidants protect neurons in Alzheimer’s disease and Parkinson’s disease,” Neurochemical Research, vol. 34, no. 4, pp. 630–638, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. A. S. Watson, M. Mortensen, and A. K. Simon, “Autophagy in the pathogenesis of myelodysplastic syndrome and acute myeloid leukemia,” Cell Cycle, vol. 10, no. 11, pp. 1719–1725, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. J. M. Matés, C. Pérez-Gómez, and I. N. de Castro, “Antioxidant enzymes and human diseases,” Clinical Biochemistry, vol. 32, no. 8, pp. 595–603, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. Y.-Z. Fang, S. Yang, and G. Wu, “Free radicals, antioxidants, and nutrition,” Nutrition, vol. 18, no. 10, pp. 872–879, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Goodman, R. M. Bostick, O. Kucuk, and D. P. Jones, “Clinical trials of antioxidants as cancer prevention agents: past, present, and future,” Free Radical Biology and Medicine, vol. 51, no. 5, pp. 1068–1084, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Ito, S. Fukushima, and H. Tsuda, “Carcinogenicity and modification of the carcinogenic response by bha, bht, and other antioxidants,” Critical Reviews in Toxicology, vol. 15, no. 2, pp. 109–150, 1985. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Kahl and H. Kappus, “Toxikologie der synthetischen Antioxidantien BHA und BHT im Vergleich mit dem natürlichen Antioxidans Vitamin E,” Zeitschrift für Lebensmittel-Untersuchung und Forschung, vol. 196, no. 4, pp. 329–338, 1993. View at Publisher · View at Google Scholar
  17. A. A. M. Botterweck, H. Verhagen, R. A. Goldbohm, J. Kleinjans, and P. A. van den Brandt, “Intake of butylated hydroxyanisole and butylated hydroxytoluene and stomach cancer risk: results from analyses in the Netherlands Cohort Study,” Food and Chemical Toxicology, vol. 38, no. 7, pp. 599–605, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Carocho and I. C. F. R. Ferreira, “A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives,” Food and Chemical Toxicology, vol. 51, no. 1, pp. 15–25, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Shetti, V. Keluskar, and A. Aggarwal, “Antioxidants: enhancing oral and general health,” Journal of Indian Academy of Oral Medicine and Radiology, vol. 21, no. 1, pp. 1–6, 2009. View at Publisher · View at Google Scholar
  20. M. Irshad and P. S. Chaudhuri, “Oxidant-antioxidant system: role and significance in human body,” Indian Journal of Experimental Biology, vol. 40, no. 11, pp. 1233–1239, 2002. View at Google Scholar · View at Scopus
  21. V. Sindhi, V. Gupta, K. Sharma, S. Bhatnagar, R. Kumari, and N. Dhaka, “Potential applications of antioxidants—a review,” Journal of Pharmacy Research, vol. 7, no. 9, pp. 828–835, 2013. View at Publisher · View at Google Scholar
  22. H. El Gharras, “Polyphenols: food sources, properties and applications—a review,” International Journal of Food Science and Technology, vol. 44, no. 12, pp. 2512–2518, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. J. M. Landete, “Updated knowledge about polyphenols: functions, bioavailability, metabolism, and health,” Critical Reviews in Food Science and Nutrition, vol. 52, no. 10, pp. 936–948, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Guerra-Araiza, A. L. Álvarez-Mejía, S. Sánchez-Torres et al., “Effect of natural exogenous antioxidants on aging and on neurodegenerative diseases,” Free Radical Research, vol. 47, no. 6-7, pp. 451–462, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Quideau, D. Deffieux, C. Douat-Casassus, and L. Pouységu, “Plant polyphenols: chemical properties, biological activities, and synthesis,” Angewandte Chemie—International Edition, vol. 50, no. 3, pp. 586–621, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. B. A. Graf, P. E. Milbury, and J. B. Blumberg, “Flavonols, flavones, flavanones, and human health: epidemiological evidence,” Journal of Medicinal Food, vol. 8, no. 3, pp. 281–290, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. D. D. Orhan, B. Özçelik, S. Özgen, and F. Ergun, “Antibacterial, antifungal, and antiviral activities of some flavonoids,” Microbiological Research, vol. 165, no. 6, pp. 496–504, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. G. Agati, E. Azzarello, S. Pollastri, and M. Tattini, “Flavonoids as antioxidants in plants: location and functional significance,” Plant Science, vol. 196, pp. 67–76, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. L. L. Bennett, S. Rojas, and T. Seefeldt, “Role of antioxidants in the prevention of cancer,” Journal of Experimental and Clinical Medicine, vol. 4, no. 4, pp. 215–222, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. L. Pérez-Rodríguez, F. Mougeot, and C. Alonso-Alvarez, “Carotenoid-based coloration predicts resistance to oxidative damage during immune challenge,” Journal of Experimental Biology, vol. 213, no. 10, pp. 1685–1690, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. A. V. Rao and L. G. Rao, “Carotenoids and human health,” Pharmacological Research, vol. 55, no. 3, pp. 207–216, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. A. I. R. N. A. Barros, F. M. Nunes, B. Gonalves, R. N. Bennett, and A. P. Silva, “Effect of cooking on total vitamin C contents and antioxidant activity of sweet chestnuts (Castanea sativa Mill.),” Food Chemistry, vol. 128, no. 1, pp. 165–172, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. M. G. Traber and J. F. Stevens, “Vitamins C and E: beneficial effects from a mechanistic perspective,” Free Radical Biology and Medicine, vol. 51, no. 5, pp. 1000–1013, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Giammanco, D. D. Majo, G. Leto, C. Flandina, M. D. Piazza, and M. L. Guardia, “The role of vitamin k in bone remodeling and osteoporosis,” Journal of Food Research, vol. 1, no. 4, article 106, 2012. View at Publisher · View at Google Scholar
  35. I. M. Puspitasari, R. Abdulah, C. Yamazaki, S. Kameo, T. Nakano, and H. Koyama, “Updates on clinical studies of selenium supplementation in radiotherapy,” Radiation Oncology, vol. 9, no. 1, article 125, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. A. S. Prasad, “Zinc: an antioxidant and anti-inflammatory agent: role of zinc in degenerative disorders of aging,” Journal of Trace Elements in Medicine and Biology, vol. 28, no. 4, pp. 364–371, 2014. View at Publisher · View at Google Scholar · View at Scopus
  37. A. Formigari, P. Irato, and A. Santon, “Zinc, antioxidant systems and metallothionein in metal mediated-apoptosis: biochemical and cytochemical aspects,” Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology, vol. 146, no. 4, pp. 443–459, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Formigari, E. Gregianin, and P. Irato, “The effect of zinc and the role of p53 in copper-induced cellular stress responses,” Journal of Applied Toxicology, vol. 33, no. 7, pp. 527–536, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. Vijayalaxmi, C. R. Thomas Jr., R. J. Reiter, and T. S. Herman, “Melatonin: from basic research to cancer treatment clinics,” Journal of Clinical Oncology, vol. 20, no. 10, pp. 2575–2601, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. G. F. Rushworth and I. L. Megson, “Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits,” Pharmacology and Therapeutics, vol. 141, no. 2, pp. 150–159, 2014. View at Publisher · View at Google Scholar · View at Scopus
  41. M. H. Carlsen, B. L. Halvorsen, K. Holte et al., “The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide,” Nutrition Journal, vol. 9, no. 1, article 3, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. F. Cattaneo, J. E. Sayago, M. R. Alberto et al., “Anti-inflammatory and antioxidant activities, functional properties and mutagenicity studies of protein and protein hydrolysate obtained from Prosopis alba seed flour,” Food Chemistry, vol. 161, pp. 391–399, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. C. F. Oliveira, D. Coletto, A. P. F. Correa et al., “Antioxidant activity and inhibition of meat lipid oxidation by soy protein hydrolysates obtained with a microbial protease,” International Food Research Journal, vol. 21, no. 2, pp. 775–781, 2014. View at Google Scholar · View at Scopus
  44. O. Vang, N. Ahmad, C. A. Baile et al., “What is new for an old molecule? systematic review and recommendations on the use of resveratrol,” PLoS ONE, vol. 6, no. 6, Article ID e19881, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. T. M. Rains, S. Agarwal, and K. C. Maki, “Antiobesity effects of green tea catechins: a mechanistic review,” Journal of Nutritional Biochemistry, vol. 22, no. 1, pp. 1–7, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. F. Thielecke and M. Boschmann, “The potential role of green tea catechins in the prevention of the metabolic syndrome—a review,” Phytochemistry, vol. 70, no. 1, pp. 11–24, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. V. Nandakumar, T. Singh, and S. K. Katiyar, “Multi-targeted prevention and therapy of cancer by proanthocyanidins,” Cancer Letters, vol. 269, no. 2, pp. 378–387, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. A. W. Boots, G. R. M. M. Haenen, and A. Bast, “Health effects of quercetin: from antioxidant to nutraceutical,” European Journal of Pharmacology, vol. 585, no. 2-3, pp. 325–337, 2008. View at Publisher · View at Google Scholar · View at Scopus
  49. C. Spagnuolo, M. Russo, S. Bilotto, I. Tedesco, B. Laratta, and G. L. Russo, “Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia,” Annals of the New York Academy of Sciences, vol. 1259, no. 1, pp. 95–103, 2012. View at Publisher · View at Google Scholar · View at Scopus
  50. Z.-R. Huang, C.-F. Hung, Y.-K. Lin, and J.-Y. Fang, “In vitro and in vivo evaluation of topical delivery and potential dermal use of soy isoflavones genistein and daidzein,” International Journal of Pharmaceutics, vol. 364, no. 1, pp. 36–44, 2008. View at Publisher · View at Google Scholar · View at Scopus
  51. E. J. Choi, “Antioxidative effects of hesperetin against 7,12-dimethylbenz(a)anthracene-induced oxidative stress in mice,” Life Sciences, vol. 82, no. 21-22, pp. 1059–1064, 2008. View at Publisher · View at Google Scholar · View at Scopus
  52. Y. Sato, S. Itagaki, T. Kurokawa et al., “In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid,” International Journal of Pharmaceutics, vol. 403, no. 1-2, pp. 136–138, 2011. View at Publisher · View at Google Scholar · View at Scopus
  53. Z. Zhao and M. H. Moghadasian, “Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: a review,” Food Chemistry, vol. 109, no. 4, pp. 691–702, 2008. View at Publisher · View at Google Scholar · View at Scopus
  54. J. P. E. Spencer, M. M. Abd El Mohsen, A.-M. Minihane, and J. C. Mathers, “Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research,” British Journal of Nutrition, vol. 99, no. 1, pp. 12–22, 2008. View at Publisher · View at Google Scholar · View at Scopus
  55. A. Scalbert, C. Manach, C. Morand, C. Rémésy, and L. Jiménez, “Dietary polyphenols and the prevention of diseases,” Critical Reviews in Food Science and Nutrition, vol. 45, no. 4, pp. 287–306, 2005. View at Publisher · View at Google Scholar · View at Scopus
  56. M. Bubonja-Sonje, J. Giacometti, and M. Abram, “Antioxidant and antilisterial activity of olive oil, cocoa and rosemary extract polyphenols,” Food Chemistry, vol. 127, no. 4, pp. 1821–1827, 2011. View at Publisher · View at Google Scholar · View at Scopus
  57. M. Calatayud, C. López-De-Dicastillo, G. López-Carballo, D. Vélez, P. Hernández Muñoz, and R. Gavara, “Active films based on cocoa extract with antioxidant, antimicrobial and biological applications,” Food Chemistry, vol. 139, no. 1–4, pp. 51–58, 2013. View at Publisher · View at Google Scholar · View at Scopus
  58. D. L. Katz, K. Doughty, and A. Ali, “Cocoa and chocolate in human health and disease,” Antioxidants and Redox Signaling, vol. 15, no. 10, pp. 2779–2811, 2011. View at Publisher · View at Google Scholar · View at Scopus
  59. D. Rossi, A. Guerrini, S. Maietti et al., “Chemical fingerprinting and bioactivity of Amazonian Ecuador Croton lechleri Müll. Arg. (Euphorbiaceae) stem bark essential oil: a new functional food ingredient?” Food Chemistry, vol. 126, no. 3, pp. 837–848, 2011. View at Publisher · View at Google Scholar · View at Scopus
  60. A. J. Alonso-Castro, E. Ortiz-Sánchez, F. Domínguez et al., “Antitumor effect of Croton lechleri Mull. Arg. (Euphorbiaceae),” Journal of Ethnopharmacology, vol. 140, no. 2, pp. 438–442, 2012. View at Publisher · View at Google Scholar · View at Scopus
  61. N. Kumari, P. Kumar, D. Mitra, B. Prasad, B. N. Tiwary, and L. Varshney, “Effects of ionizing radiation on microbial decontamination, phenolic contents, and antioxidant properties of Triphala,” Journal of Food Science, vol. 74, no. 3, pp. M109–M113, 2009. View at Publisher · View at Google Scholar · View at Scopus
  62. A. Shehzad, J. Lee, and Y. S. Lee, “Curcumin in various cancers,” BioFactors, vol. 39, no. 1, pp. 56–68, 2013. View at Publisher · View at Google Scholar · View at Scopus
  63. M. Salem, S. Rohani, and E. R. Gillies, “Curcumin, a promising anti-cancer therapeutic: a review of its chemical properties, bioactivity and approaches to cancer cell delivery,” RSC Advances, vol. 4, no. 21, pp. 10815–10829, 2014. View at Publisher · View at Google Scholar · View at Scopus
  64. S. S. Boyanapalli and A. T. Kong, “‘Curcumin, the king of spices’: epigenetic regulatory mechanisms in the prevention of cancer, neurological, and inflammatory diseases,” Current Pharmacology Reports, vol. 1, no. 2, pp. 129–139, 2015. View at Publisher · View at Google Scholar
  65. L. H. Kushi, C. Doyle, M. McCullough et al., “American Cancer Society guidelines on nutrition and physical activity for cancer prevention,” CA Cancer Journal for Clinicians, vol. 62, no. 1, pp. 30–67, 2012. View at Publisher · View at Google Scholar · View at Scopus
  66. Y.-J. Surh, “Nrf2, an essential component of cellular stress response, as a potential target of hormetic phytochemicals,” Journal of Food and Drug Analysis, vol. 20, no. 1, pp. 217–219, 2012. View at Google Scholar · View at Scopus
  67. B. Bozin, N. Mimica-Dukic, I. Samojlik, and E. Jovin, “Antimicrobial and antioxidant properties of Rosemary and Sage (Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae) essential oils,” Journal of Agricultural and Food Chemistry, vol. 55, no. 19, pp. 7879–7885, 2007. View at Publisher · View at Google Scholar · View at Scopus
  68. M. M. Özcan and D. Arslan, “Antioxidant effect of essential oils of rosemary, clove and cinnamon on hazelnut and poppy oils,” Food Chemistry, vol. 129, no. 1, pp. 171–174, 2011. View at Publisher · View at Google Scholar · View at Scopus
  69. D. Krishnaiah, R. Sarbatly, and R. Nithyanandam, “A review of the antioxidant potential of medicinal plant species,” Food and Bioproducts Processing, vol. 89, no. 3, pp. 217–233, 2011. View at Publisher · View at Google Scholar · View at Scopus
  70. R. Estruch, E. Ros, J. Salas-Salvadó et al., “Primary prevention of cardiovascular disease with a Mediterranean diet,” The New England Journal of Medicine, vol. 368, no. 14, pp. 1279–1290, 2013. View at Publisher · View at Google Scholar · View at Scopus
  71. E. H. Martinez-Lapiscina, P. Clavero, E. Toledo et al., “Virgin olive oil supplementation and long-term cognition: the Predimed-Navarra randomized, trial,” Journal of Nutrition, Health and Aging, vol. 17, no. 6, pp. 544–552, 2013. View at Publisher · View at Google Scholar · View at Scopus
  72. A. Hartmann, C.-D. Patz, W. Andlauer, H. Dietrich, and M. Ludwig, “Influence of processing on quality parameters of strawberries,” Journal of Agricultural and Food Chemistry, vol. 56, no. 20, pp. 9484–9489, 2008. View at Publisher · View at Google Scholar · View at Scopus
  73. J. Dai and R. J. Mumper, “Plant phenolics: extraction, analysis and their antioxidant and anticancer properties,” Molecules, vol. 15, no. 10, pp. 7313–7352, 2010. View at Publisher · View at Google Scholar · View at Scopus
  74. D. G. Lindsay and S. B. Astley, “European research on the functional effects of dietary antioxidants—EUROFEDA,” Molecular Aspects of Medicine, vol. 23, no. 1–3, pp. 1–38, 2002. View at Publisher · View at Google Scholar · View at Scopus
  75. N. Z. Unlu, T. Bohn, D. M. Francis, H. Nagaraja, S. K. Clinton, and S. J. Schwartz, “Lycopene from heat-induced cis-isomer-rich tomato sauce is more bioavailable than from all-trans-rich tomato sauce in human subjects,” British Journal of Nutrition, vol. 98, no. 1, pp. 140–146, 2007. View at Publisher · View at Google Scholar · View at Scopus
  76. T. Ozben, “Antioxidant supplementation on cancer risk and during cancer therapy: an update,” Current Topics in Medicinal Chemistry, vol. 15, no. 2, pp. 170–178, 2015. View at Google Scholar
  77. K. Radimer, B. Bindewald, J. Hughes, B. Ervin, C. Swanson, and M. F. Picciano, “Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999-2000,” The American Journal of Epidemiology, vol. 160, no. 4, pp. 339–349, 2004. View at Publisher · View at Google Scholar · View at Scopus
  78. J. B. Penié and A. R. E. Alfonso, “Papel de la nutrición en la prevención de la enfermedad aterosclerótica. Importancia de los suplementos dietéticos: nutracéuticos,” Revista Española de Cardiología Suplementos, vol. 11, pp. 13–17, 2011. View at Publisher · View at Google Scholar
  79. R. L. Bailey, J. J. Gahche, P. E. Miller, P. R. Thomas, and J. T. Dwyer, “Why US adults use dietary supplements,” JAMA Internal Medicine, vol. 173, no. 5, pp. 355–361, 2013. View at Publisher · View at Google Scholar · View at Scopus
  80. G. Skeie, T. Braaten, A. Hjartåker et al., “Use of dietary supplements in the European Prospective Investigation into Cancer and Nutrition calibration study,” European Journal of Clinical Nutrition, vol. 63, no. 4, pp. S226–S238, 2009. View at Publisher · View at Google Scholar · View at Scopus
  81. A. Kunwar and K. I. Priyadarsini, “Free radicals, oxidative stress and importance of antioxidants in human health,” Journal of Medical and Allied Sciences, vol. 1, no. 2, pp. 53–60, 2011. View at Google Scholar
  82. H.-Y. Huang, B. Caballero, S. Chang et al., “Multivitamin/mineral supplements and prevention of chronic disease: executive summary,” American Journal of Clinical Nutrition, vol. 85, no. 1, pp. 265S–268S, 2007. View at Google Scholar · View at Scopus
  83. J. W. Lee and J. M. Davis, “Future applications of antioxidants in premature infants,” Current Opinion in Pediatrics, vol. 23, no. 2, pp. 161–166, 2011. View at Publisher · View at Google Scholar · View at Scopus
  84. A. Agarwal and L. H. Sekhon, “The role of antioxidant therapy in the treatment of male infertility,” Human Fertility, vol. 13, no. 4, pp. 217–225, 2010. View at Publisher · View at Google Scholar · View at Scopus
  85. D. J. Loren, N. P. Seeram, R. N. Schulman, and D. M. Holtzman, “Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury,” Pediatric Research, vol. 57, no. 6, pp. 858–864, 2005. View at Publisher · View at Google Scholar · View at Scopus
  86. T. West, M. Atzeva, and D. M. Holtzman, “Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic-ischemic injury,” Developmental Neuroscience, vol. 29, no. 4-5, pp. 363–372, 2007. View at Publisher · View at Google Scholar · View at Scopus
  87. T. P. A. Devasagayam, J. C. Tilak, K. K. Boloor, K. S. Sane, S. S. Ghaskadbi, and R. D. Lele, “Free radicals and antioxidants in human health: current status and future prospects,” Journal of Association of Physicians of India, vol. 52, pp. 794–804, 2004. View at Google Scholar · View at Scopus
  88. A. Godic, B. Poljšak, M. Adamic, and R. Dahmane, “The role of antioxidants in skin cancer prevention and treatment,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 860479, 6 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  89. M. Mushtaq and S. M. Wani, “Polyphenols and human health—a review,” International Journal of Pharma and Bio Sciences, vol. 4, no. 2, pp. B338–B360, 2013. View at Google Scholar · View at Scopus
  90. N. Kandasamy and N. Ashokkumar, “Protective effect of bioflavonoid myricetin enhances carbohydrate metabolic enzymes and insulin signaling molecules in streptozotocin-cadmium induced diabetic nephrotoxic rats,” Toxicology and Applied Pharmacology, vol. 279, no. 2, pp. 173–185, 2014. View at Publisher · View at Google Scholar · View at Scopus
  91. K. Maeda, M. Kuzuya, X. W. Cheng et al., “Green tea catechins inhibit the cultured smooth muscle cell invasion through the basement barrier,” Atherosclerosis, vol. 166, no. 1, pp. 23–30, 2003. View at Publisher · View at Google Scholar · View at Scopus
  92. Y. Miura, T. Chiba, I. Tomita et al., “Tea catechins prevent the development of atherosclerosis in apoprotein E-deficient mice,” Journal of Nutrition, vol. 131, no. 1, pp. 27–32, 2001. View at Google Scholar · View at Scopus
  93. M. Kaplan, T. Hayek, A. Raz et al., “Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis,” Journal of Nutrition, vol. 131, no. 8, pp. 2082–2089, 2001. View at Google Scholar · View at Scopus
  94. P. Russo, I. Tedesco, M. Russo, G. L. Russo, A. Venezia, and C. Cicala, “Effects of de-alcoholated red wine and its phenolic fractions on platelet aggregation,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 11, no. 1, pp. 25–29, 2001. View at Google Scholar · View at Scopus
  95. A. A. A. Bertelli and D. K. Das, “Grapes, wines, resveratrol, and heart health,” Journal of Cardiovascular Pharmacology, vol. 54, no. 6, pp. 468–476, 2009. View at Publisher · View at Google Scholar · View at Scopus
  96. L. Letenneur, C. Proust-Lima, A. L. Gouge, J. F. Dartigues, and P. Barberger-Gateau, “Flavonoid intake and cognitive decline over a 10-year period,” The American Journal of Epidemiology, vol. 165, no. 12, pp. 1364–1371, 2007. View at Publisher · View at Google Scholar · View at Scopus
  97. A. Ebrahimi and H. Schluesener, “Natural polyphenols against neurodegenerative disorders: potentials and pitfalls,” Ageing Research Reviews, vol. 11, no. 2, pp. 329–345, 2012. View at Publisher · View at Google Scholar · View at Scopus
  98. A. Swaminathan and G. A. Jicha, “Nutrition and prevention of Alzheimer’s dementia,” Frontiers in Aging Neuroscience, vol. 6, article 282, 2014. View at Publisher · View at Google Scholar · View at Scopus
  99. Q. Dai, A. R. Borenstein, Y. Wu, J. C. Jackson, and E. B. Larson, “Fruit and vegetable juices and Alzheimer’s disease: the Kame project,” American Journal of Medicine, vol. 119, no. 9, pp. 751–759, 2006. View at Publisher · View at Google Scholar · View at Scopus
  100. V. Vingtdeux, U. Dreses-Werringloer, H. Zhao, P. Davies, and P. Marambaud, “Therapeutic potential of resveratrol in Alzheimer’s disease,” BMC Neuroscience, vol. 9, supplement 2, article S6, 2008. View at Publisher · View at Google Scholar · View at Scopus
  101. M. Valko, D. Leibfritz, J. Moncol, M. T. D. Cronin, M. Mazur, and J. Telser, “Free radicals and antioxidants in normal physiological functions and human disease,” International Journal of Biochemistry and Cell Biology, vol. 39, no. 1, pp. 44–84, 2007. View at Publisher · View at Google Scholar · View at Scopus
  102. M.-L. Hu, “Dietary polyphenols as antioxidants and anticancer agents: more questions than answers,” Chang Gung Medical Journal, vol. 34, no. 5, pp. 449–460, 2011. View at Google Scholar · View at Scopus
  103. J. A. Baur and D. A. Sinclair, “Therapeutic potential of resveratrol: the in vivo evidence,” Nature Reviews Drug Discovery, vol. 5, no. 6, pp. 493–506, 2006. View at Publisher · View at Google Scholar · View at Scopus
  104. M. Lu, B. Yuan, M. Zeng, and J. Chen, “Antioxidant capacity and major phenolic compounds of spices commonly consumed in China,” Food Research International, vol. 44, no. 2, pp. 530–536, 2011. View at Publisher · View at Google Scholar · View at Scopus
  105. M. Athar, J. H. Back, X. Tang et al., “Resveratrol: a review of preclinical studies for human cancer prevention,” Toxicology and Applied Pharmacology, vol. 224, no. 3, pp. 274–283, 2007. View at Publisher · View at Google Scholar · View at Scopus
  106. M. Vaz-da-Silva, A. I. Loureiro, A. Falcao et al., “Effect of food on the pharmacokinetic profile of trans-resveratrol,” International Journal of Clinical Pharmacology and Therapeutics, vol. 46, no. 11, pp. 564–570, 2008. View at Publisher · View at Google Scholar · View at Scopus
  107. M. Emília Juan, M. Pilar Vinardell, and J. M. Planas, “The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful,” Journal of Nutrition, vol. 132, no. 2, pp. 257–260, 2002. View at Google Scholar · View at Scopus
  108. M. Cortés-Jofré, J.-R. Rueda, G. Corsini-Muñoz, C. Fonseca-Cortés, M. Caraballoso, and X. Bonfill Cosp, “Drugs for preventing lung cancer in healthy people,” Cochrane Database of Systematic Reviews, vol. 10, Article ID CD002141, 2012. View at Google Scholar · View at Scopus
  109. J. Virtamo, P. R. Taylor, J. Kontto et al., “Effects of α-tocopherol and β-carotene supplementation on cancer incidence and mortality: 18-year postintervention follow-up of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study,” International Journal of Cancer, vol. 135, no. 1, pp. 178–185, 2014. View at Publisher · View at Google Scholar · View at Scopus
  110. J. M. Lappe, D. Travers-Gustafson, K. M. Davies, R. R. Recker, and R. P. Heaney, “Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial,” The American Journal of Clinical Nutrition, vol. 85, no. 6, pp. 1586–1591, 2007. View at Google Scholar · View at Scopus
  111. Y.-L. Qiao, S. M. Dawsey, F. Kamangar et al., “Total and cancer mortality after supplementation with vitamins and minerals: follow-up of the linxian general population nutrition intervention trial,” Journal of the National Cancer Institute, vol. 101, no. 7, pp. 507–518, 2009. View at Publisher · View at Google Scholar · View at Scopus
  112. H. Hoensch, B. Groh, L. Edler, and W. Kirch, “Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence,” World Journal of Gastroenterology, vol. 14, no. 14, pp. 2187–2193, 2008. View at Publisher · View at Google Scholar · View at Scopus
  113. G. Bobe, L. B. Sansbury, P. S. Albert et al., “Dietary flavonoids and colorectal adenoma recurrence in the polyp prevention trial,” Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 6, pp. 1344–1353, 2008. View at Publisher · View at Google Scholar · View at Scopus
  114. B. N. Singh, S. Shankar, and R. K. Srivastava, “Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications,” Biochemical Pharmacology, vol. 82, no. 12, pp. 1807–1821, 2011. View at Publisher · View at Google Scholar · View at Scopus
  115. C. S. Yang, X. Wang, G. Lu, and S. C. Picinich, “Cancer prevention by tea: animal studies, molecular mechanisms and human relevance,” Nature Reviews Cancer, vol. 9, no. 6, pp. 429–439, 2009. View at Publisher · View at Google Scholar · View at Scopus
  116. I. Bairati, F. Meyer, M. Gélinas et al., “Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck cancer patients,” Journal of Clinical Oncology, vol. 23, no. 24, pp. 5805–5813, 2005. View at Publisher · View at Google Scholar · View at Scopus
  117. I. Bairati, F. Meyer, E. Jobin et al., “Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients,” International Journal of Cancer, vol. 119, no. 9, pp. 2221–2224, 2006. View at Publisher · View at Google Scholar · View at Scopus
  118. V. Fuchs-Tarlovsky, M. Bejarano-Rosales, G. Gutierrez-Salmean, M. A. Casillas, J. C. Lopez-Alvarenga, and G. M. Ceballos-Reyes, “Efecto de la suplementación con antioxidantes sobre el estrés oxidativo y la calidad de vida durante el tratamiento oncológico en pacientes con cáncer cérvico uterino,” Nutricion Hospitalaria, vol. 26, no. 4, pp. 819–826, 2011. View at Publisher · View at Google Scholar · View at Scopus
  119. G. Zhang, Y. Wang, Y. Zhang et al., “Anti-cancer activities of tea epigallocatechin-3-gallate in breast cancer patients under radiotherapy,” Current Molecular Medicine, vol. 12, no. 2, pp. 163–176, 2012. View at Publisher · View at Google Scholar · View at Scopus
  120. M. D. C. Santos Araújo, I. L. Farias, J. Gutierres et al., “Uncaria tomentosa—adjuvant treatment for breast cancer: clinical trial,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 676984, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  121. Y. Al-Tonbary, M. Al-Haggar, R. El-Ashry, S. El-Dakroory, H. Azzam, and A. Fouda, “Vitamin e and N-acetylcysteine as antioxidant adjuvant therapy in children with acute lymphoblastic leukemia,” Advances in Hematology, vol. 2009, Article ID 689639, 5 pages, 2009. View at Publisher · View at Google Scholar · View at Scopus
  122. P. Lissoni, “Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms,” Pathologie Biologie, vol. 55, no. 3-4, pp. 201–204, 2007. View at Publisher · View at Google Scholar · View at Scopus
  123. A. Sookprasert, N. P. Johns, A. Pnunmanee et al., “Melatonin in patients with cancer receiving chemotherapy: a randomized, double-blind, placebo-controlled trial,” Anticancer Research, vol. 34, no. 12, pp. 7327–7337, 2014. View at Google Scholar · View at Scopus
  124. A. Khafif, S. Lev-Ari, A. Vexler et al., “Curcumin: a potential radio-enhancer in head and neck cancer,” Laryngoscope, vol. 119, no. 10, pp. 2019–2026, 2009. View at Publisher · View at Google Scholar · View at Scopus
  125. E. Lecumberri, Y. M. Dupertuis, R. Miralbell, and C. Pichard, “Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy,” Clinical Nutrition, vol. 32, no. 6, pp. 894–903, 2013. View at Publisher · View at Google Scholar · View at Scopus
  126. A. Shirazi, G. Ghobadi, and M. Ghazi-Khansari, “A radiobiological review on melatonin: a novel radioprotector,” Journal of Radiation Research, vol. 48, no. 4, pp. 263–272, 2007. View at Publisher · View at Google Scholar · View at Scopus
  127. X.-Y. Wu, A.-Y. Luo, Y.-R. Zhou, and J.-H. Ren, “N-acetylcysteine reduces oxidative stress, nuclear factor-κB activity and cardiomyocyte apoptosis in heart failure,” Molecular Medicine Reports, vol. 10, no. 2, pp. 615–624, 2014. View at Publisher · View at Google Scholar · View at Scopus
  128. M. L. Heaney, J. R. Gardner, N. Karasavvas et al., “Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs,” Cancer Research, vol. 68, no. 19, pp. 8031–8038, 2008. View at Publisher · View at Google Scholar · View at Scopus
  129. C. McDonald, J. Muhlbauer, G. Perlmutter, K. Taparra, and S. A. Phelan, “Peroxiredoxin proteins protect MCF-7 breast cancer cells from doxorubicin-induced toxicity,” International Journal of Oncology, vol. 45, no. 1, pp. 219–226, 2014. View at Publisher · View at Google Scholar · View at Scopus
  130. G. Liang, A. Tang, X. Lin et al., “Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer,” International Journal of Oncology, vol. 37, no. 1, pp. 111–123, 2010. View at Publisher · View at Google Scholar · View at Scopus
  131. M. Fukui, N. Yamabe, and B. T. Zhu, “Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells in vitro and in vivo,” European Journal of Cancer, vol. 46, no. 10, pp. 1882–1891, 2010. View at Publisher · View at Google Scholar · View at Scopus
  132. S. Tabaczar, A. Koceva-Chyla, J. Czepas, A. Pieniazek, J. Piasecka-Zelga, and K. Gwozdzinski, “Nitroxide pirolin reduces oxidative stress generated by doxorubicin and docetaxel in blood plasma of rats bearing mammary tumor,” Journal of Physiology and Pharmacology, vol. 63, no. 2, pp. 153–163, 2012. View at Google Scholar · View at Scopus
  133. N. Li, C. Sun, B. Zhou et al., “Low concentration of quercetin antagonizes the cytotoxic effects of anti-neoplastic drugs in ovarian cancer,” PLoS ONE, vol. 9, no. 7, Article ID e100314, 2014. View at Publisher · View at Google Scholar · View at Scopus
  134. H. Ma, T. Das, S. Pereira et al., “Efficacy of dietary antioxidants combined with a chemotherapeutic agent on human colon cancer progression in a fluorescent orthotopic mouse model,” Anticancer Research, vol. 29, no. 7, pp. 2421–2426, 2009. View at Google Scholar · View at Scopus
  135. M. Notarbartolo, P. Poma, D. Perri, L. Dusonchet, M. Cervello, and N. D’Alessandro, “Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells. Analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expression,” Cancer Letters, vol. 224, no. 1, pp. 53–65, 2005. View at Publisher · View at Google Scholar · View at Scopus
  136. R. Wilken, M. S. Veena, M. B. Wang, and E. S. Srivatsan, “Curcumin: a review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma,” Molecular Cancer, vol. 10, article 12, 2011. View at Publisher · View at Google Scholar · View at Scopus
  137. Y. J. Wu, L. L. Muldoon, and E. A. Neuwelt, “The chemoprotective agent N-acetylcysteine blocks cisplatin-induced apoptosis through caspase signaling pathway,” Journal of Pharmacology and Experimental Therapeutics, vol. 312, no. 2, pp. 424–431, 2005. View at Publisher · View at Google Scholar · View at Scopus
  138. D. T. Dickey, L. L. Muldoon, D. F. Kraemer, and E. A. Neuwelt, “Protection against cisplatin-induced ototoxicity by N-acetylcysteine in a rat model,” Hearing Research, vol. 193, no. 1-2, pp. 25–30, 2004. View at Publisher · View at Google Scholar · View at Scopus
  139. A. Atessahin, S. Yilmaz, I. Karahan, A. O. Ceribasi, and A. Karaoglu, “Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats,” Toxicology, vol. 212, no. 2-3, pp. 116–123, 2005. View at Publisher · View at Google Scholar · View at Scopus
  140. F. Meyer, P. Galan, P. Douville et al., “Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial,” International Journal of Cancer, vol. 116, no. 2, pp. 182–186, 2005. View at Publisher · View at Google Scholar · View at Scopus
  141. S. Hercberg, S. Czernichow, and P. Galan, “Tell me what your blood β-carotene level is, I will tell you what your health risk is! The viewpoint of the SUVIMAX researchers,” Annals of Nutrition and Metabolism, vol. 54, no. 4, pp. 310–312, 2009. View at Publisher · View at Google Scholar · View at Scopus
  142. P. Greenwald, D. Anderson, S. A. Nelson, and P. R. Taylor, “Clinical trials of vitamin and mineral supplements for cancer prevention,” American Journal of Clinical Nutrition, vol. 85, no. 1, pp. 314S–317S, 2007. View at Google Scholar · View at Scopus
  143. A. M. Algotar, M. S. Stratton, F. R. Ahmann et al., “Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer,” Prostate, vol. 73, no. 3, pp. 328–335, 2013. View at Publisher · View at Google Scholar · View at Scopus
  144. X. Han, J. Li, T. M. Brasky et al., “Antioxidant intake and pancreatic cancer risk: the Vitamins and Lifestyle (VITAL) Study,” Cancer, vol. 119, no. 7, pp. 1314–1320, 2013. View at Publisher · View at Google Scholar · View at Scopus
  145. G. A. Sonn, W. Aronson, and M. S. Litwin, “Impact of diet on prostate cancer: a review,” Prostate Cancer and Prostatic Diseases, vol. 8, no. 4, pp. 304–310, 2005. View at Publisher · View at Google Scholar · View at Scopus
  146. M. S. Geybels, P. A. van den Brandt, F. J. van Schooten, and B. A. J. Verhage, “Oxidative stress-related genetic variants, pro- and antioxidant intake and status, and advanced prostate cancer risk,” Cancer Epidemiology Biomarkers and Prevention, vol. 24, no. 1, pp. 178–186, 2015. View at Publisher · View at Google Scholar · View at Scopus
  147. N. E. Fleshner, L. Kapusta, B. Donnelly et al., “Progression from high-grade prostatic intraepithelial neoplasia to cancer: a randomized trial of combination vitamin-E, soy, and selenium,” Journal of Clinical Oncology, vol. 29, no. 17, pp. 2386–2390, 2011. View at Publisher · View at Google Scholar · View at Scopus
  148. P. Feng, T. L. Li, Z. X. Guan, R. B. Franklin, and L. C. Costello, “Effect of zinc on prostatic tumorigenicity in nude mice,” Annals of the New York Academy of Sciences, vol. 1010, pp. 316–320, 2003. View at Publisher · View at Google Scholar · View at Scopus
  149. R. G. Uzzo, P. Leavis, W. Hatch et al., “Zinc inhibits nuclear factor-κB activation and sensitizes prostate cancer cells to cytotoxic agents,” Clinical Cancer Research, vol. 8, no. 11, pp. 3579–3583, 2002. View at Google Scholar · View at Scopus
  150. L. C. Costello, R. B. Franklin, P. Feng, M. Tan, and O. Bagasra, “Zinc and prostate cancer: a critical scientific, medical, and public interest issue (United States),” Cancer Causes and Control, vol. 16, no. 8, pp. 901–915, 2005. View at Publisher · View at Google Scholar · View at Scopus
  151. M. F. Leitzmann, M. J. Stampfer, K. Wu, G. A. Colditz, W. C. Willett, and E. L. Giovannucci, “Zinc supplement use and risk of prostate cancer,” Journal of the National Cancer Institute, vol. 95, no. 13, pp. 1004–1007, 2003. View at Publisher · View at Google Scholar · View at Scopus
  152. E. Ho, “Zinc deficiency, DNA damage and cancer risk,” Journal of Nutritional Biochemistry, vol. 15, no. 10, pp. 572–578, 2004. View at Publisher · View at Google Scholar · View at Scopus
  153. W. J. Verret, Y. Chen, A. Ahmed et al., “A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh,” Journal of Occupational and Environmental Medicine, vol. 47, no. 10, pp. 1026–1035, 2005. View at Publisher · View at Google Scholar · View at Scopus
  154. V. I. Sayin, M. X. Ibrahim, E. Larsson, J. A. Nilsson, P. Lindahl, and M. O. Bergo, “Antioxidants accelerate lung cancer progression in mice,” Science Translational Medicine, vol. 6, no. 221, pp. 221–ra15, 2014. View at Publisher · View at Google Scholar · View at Scopus
  155. J. M. Matés, J. A. Segura, F. J. Alonso, and J. Márquez, “Oxidative stress in apoptosis and cancer: an update,” Archives of Toxicology, vol. 86, no. 11, pp. 1649–1665, 2012. View at Publisher · View at Google Scholar · View at Scopus
  156. S. Reuter, S. C. Gupta, M. M. Chaturvedi, and B. B. Aggarwal, “Oxidative stress, inflammation, and cancer: how are they linked?” Free Radical Biology and Medicine, vol. 49, no. 11, pp. 1603–1616, 2010. View at Publisher · View at Google Scholar · View at Scopus
  157. A. H. Wyllie, “‘Where, O death, is thy sting?’ A brief review of apoptosis biology,” Molecular Neurobiology, vol. 42, no. 1, pp. 4–9, 2010. View at Publisher · View at Google Scholar · View at Scopus
  158. T. Nguyen, P. Nioi, and C. B. Pickett, “The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress,” The Journal of Biological Chemistry, vol. 284, no. 20, pp. 13291–13295, 2009. View at Publisher · View at Google Scholar · View at Scopus
  159. A. A. Sablina, A. V. Budanov, G. V. Ilyinskaya, L. S. Agapova, J. E. Kravchenko, and P. M. Chumakov, “The antioxidant function of the p53 tumor suppressor,” Nature Medicine, vol. 11, no. 12, pp. 1306–1313, 2005. View at Publisher · View at Google Scholar · View at Scopus
  160. E. Gottlieb and K. H. Vousden, “p53 regulation of metabolic pathways,” Cold Spring Harbor Perspectives in Biology, vol. 2, no. 4, Article ID a001040, 2010. View at Publisher · View at Google Scholar · View at Scopus
  161. C. Gorrini, I. S. Harris, and T. W. Mak, “Modulation of oxidative stress as an anticancer strategy,” Nature Reviews Drug Discovery, vol. 12, no. 12, pp. 931–947, 2013. View at Publisher · View at Google Scholar · View at Scopus
  162. V. Fuchs-Tarlovsky, “Role of antioxidants in cancer therapy,” Nutrition, vol. 29, no. 1, pp. 15–21, 2013. View at Publisher · View at Google Scholar · View at Scopus
  163. D. R. Spitz, E. I. Azzam, J. J. Li, and D. Gius, “Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology,” Cancer and Metastasis Reviews, vol. 23, no. 3-4, pp. 311–322, 2004. View at Publisher · View at Google Scholar · View at Scopus
  164. K. Roszkowski, D. Gackowski, R. Rozalski et al., “Small field radiotherapy of head and neck cancer patients is responsible for oxidatively damaged DNA/oxidative stress on the level of a whole organism,” International Journal of Cancer, vol. 123, no. 8, pp. 1964–1967, 2008. View at Publisher · View at Google Scholar · View at Scopus
  165. N. Suhail, N. Bilal, H. Y. Khan et al., “Effect of vitamins C and e on antioxidant status of breast-cancer patients undergoing chemotherapy,” Journal of Clinical Pharmacy and Therapeutics, vol. 37, no. 1, pp. 22–26, 2012. View at Publisher · View at Google Scholar · View at Scopus
  166. T. Masahiko, N. Tsunehiko, and K. Tsutomu, “Clinical trial of adverse effect inhibition with glucosides of vitamin C and vitamin E in radiotherapy and chemotherapy,” Journal of Cancer Research and Therapeutics, vol. 1, no. 4, p. 239, 2005. View at Publisher · View at Google Scholar · View at Scopus
  167. C. Vollbracht, B. Schneider, V. Leendert, G. Weiss, L. Auerbach, and J. Beuth, “Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany,” In Vivo, vol. 25, no. 6, pp. 983–990, 2011. View at Google Scholar
  168. B. D. Lawenda, K. M. Kelly, E. J. Ladas, S. M. Sagar, A. Vickers, and J. B. Blumberg, “Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?” Journal of the National Cancer Institute, vol. 100, no. 11, pp. 773–783, 2008. View at Publisher · View at Google Scholar · View at Scopus
  169. G. C. Jagetia, “Radioprotection and radiosensitization by curcumin,” Advances in Experimental Medicine and Biology, vol. 595, pp. 301–320, 2007. View at Publisher · View at Google Scholar · View at Scopus
  170. D. Chendil, R. S. Ranga, D. Meigooni, S. Sathishkumar, and M. M. Ahmed, “Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3,” Oncogene, vol. 23, no. 8, pp. 1599–1607, 2004. View at Publisher · View at Google Scholar · View at Scopus
  171. B. B. Aggarwal, S. Shishodia, Y. Takada et al., “Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice,” Clinical Cancer Research, vol. 11, no. 20, pp. 7490–7498, 2005. View at Publisher · View at Google Scholar · View at Scopus
  172. S. K. Sandur, A. Deorukhkar, M. K. Pandey et al., “Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-κB activity,” International Journal of Radiation Oncology Biology Physics, vol. 75, no. 2, pp. 534–542, 2009. View at Publisher · View at Google Scholar · View at Scopus
  173. M. M. Yallapu, D. M. Maher, V. Sundram, M. C. Bell, M. Jaggi, and S. C. Chauhan, “Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth,” Journal of Ovarian Research, vol. 3, no. 1, article 11, 2010. View at Publisher · View at Google Scholar · View at Scopus
  174. C.-L. Yang, Y.-Y. Liu, Y.-G. Ma et al., “Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through janus kinase-STAT3 signalling pathway,” PLoS ONE, vol. 7, no. 5, Article ID e37960, 2012. View at Publisher · View at Google Scholar · View at Scopus
  175. Vijayalaxmi, R. J. Reiter, M. L. Meltz, and T. S. Herman, “Melatonin: possible mechanisms involved in its ‘radioprotective’ effect,” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 404, no. 1-2, pp. 187–189, 1998. View at Publisher · View at Google Scholar · View at Scopus
  176. E. Carrasco, P. J. Álvarez, C. Melguizo et al., “Novel merosesquiterpene exerts a potent antitumor activity against breast cancer cells in vitro and in vivo,” European Journal of Medicinal Chemistry, vol. 79, pp. 1–12, 2014. View at Publisher · View at Google Scholar · View at Scopus
  177. S. R. Hall, H. L. Blundon, M. A. Ladda et al., “Jadomycin breast cancer cytotoxicity is mediated by a copper-dependent, reactive oxygen species-inducing mechanism,” Pharmacology Research & Perspectives, vol. 3, no. 2, 2015. View at Publisher · View at Google Scholar
  178. M. Sereno, G. Gutiérrez-Gutiérrez, C. Gómez-Raposo et al., “Oxaliplatin induced-neuropathy in digestive tumors,” Critical Reviews in Oncology/Hematology, vol. 89, no. 1, pp. 166–178, 2014. View at Publisher · View at Google Scholar · View at Scopus
  179. H. Takahashi, F. Yamaguchi, and A. Teramoto, “Long-term outcome and reconsideration of intracystic chemotherapy with bleomycin for craniopharyngioma in children,” Child’s Nervous System, vol. 21, no. 8-9, pp. 701–704, 2005. View at Publisher · View at Google Scholar · View at Scopus
  180. J.-L. Lee, S. C. Kim, J.-H. Kim et al., “Prospective efficacy and safety study of neoadjuvant gemcitabine with capecitabine combination chemotherapy for borderline-resectable or unresectable locally advanced pancreatic adenocarcinoma,” Surgery, vol. 152, no. 5, pp. 851–862, 2012. View at Publisher · View at Google Scholar · View at Scopus
  181. J.-Y. Han, K. Park, S.-W. Kim et al., “First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung,” Journal of Clinical Oncology, vol. 30, no. 10, pp. 1122–1128, 2012. View at Publisher · View at Google Scholar · View at Scopus
  182. X. Wei, F. Su, X. Su, T. Hu, and S. Hu, “Stereospecific antioxidant effects of ginsenoside Rg3 on oxidative stress induced by cyclophosphamide in mice,” Fitoterapia, vol. 83, no. 4, pp. 636–642, 2012. View at Publisher · View at Google Scholar · View at Scopus
  183. M. B. Azad, Y. Chen, and S. B. Gibson, “Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment,” Antioxidants and Redox Signaling, vol. 11, no. 4, pp. 777–790, 2009. View at Publisher · View at Google Scholar · View at Scopus
  184. Á. Arjona-Sánchez, J. Ruiz-Rabelo, M. D. Perea et al., “Effects of capecitabine and celecoxib in experimental pancreatic cancer,” Pancreatology, vol. 10, no. 5, pp. 641–647, 2010. View at Publisher · View at Google Scholar · View at Scopus
  185. H. Pelicano, D. Carney, and P. Huang, “ROS stress in cancer cells and therapeutic implications,” Drug Resistance Updates, vol. 7, no. 2, pp. 97–110, 2004. View at Publisher · View at Google Scholar · View at Scopus
  186. J. F. San Miguel, R. Schlag, N. K. Khuageva et al., “Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma,” The New England Journal of Medicine, vol. 359, no. 9, pp. 906–917, 2008. View at Publisher · View at Google Scholar · View at Scopus
  187. Y.-H. Ling, L. Liebes, Y. Zou, and R. Perez-Soler, “Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells,” Journal of Biological Chemistry, vol. 278, no. 36, pp. 33714–33723, 2003. View at Publisher · View at Google Scholar · View at Scopus
  188. H.-H. Zhu, D.-P. Wu, J. Jin et al., “Oral tetra-arsenic tetra-sulfide formula versus intravenous arsenic trioxide as first-line treatment of acute promyelocytic leukemia: a multicenter randomized controlled trial,” Journal of Clinical Oncology, vol. 31, no. 33, pp. 4215–4221, 2013. View at Publisher · View at Google Scholar · View at Scopus
  189. J. Zhou, “Arsenic trioxide: an ancient drug revived,” Chinese Medical Journal, vol. 125, no. 19, pp. 3556–3560, 2012. View at Publisher · View at Google Scholar · View at Scopus
  190. M. S. Tallman, “What is the role of arsenic in newly diagnosed APL?” Best Practice & Research: Clinical Haematology, vol. 21, no. 4, pp. 659–666, 2008. View at Publisher · View at Google Scholar · View at Scopus
  191. F. Ravandi, E. Estey, D. Jones et al., “Effective treatment of acute promyelocytic leukemia with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin,” Journal of Clinical Oncology, vol. 27, no. 4, pp. 504–510, 2009. View at Publisher · View at Google Scholar · View at Scopus
  192. Y. M. Chung, Y. S. Bae, and S. Y. Lee, “Molecular ordering of ROS production, mitochondrial changes, and caspase activation during sodium salicylate-induced apoptosis,” Free Radical Biology and Medicine, vol. 34, no. 4, pp. 434–442, 2003. View at Publisher · View at Google Scholar · View at Scopus
  193. O. Mir, J. Alexandre, A. Tran et al., “Relationship between GSTP1 Ile 105Val polymorphism and docetaxel-induced peripheral neuropathy: clinical evidence of a role of oxidative stress in taxane toxicity,” Annals of Oncology, vol. 20, no. 4, pp. 736–740, 2009. View at Publisher · View at Google Scholar · View at Scopus
  194. A. Thorburn and A. E. Frandel, “Apoptosis and anthracycline cardiotoxicity,” Molecular Cancer Therapeutics, vol. 5, no. 2, pp. 197–199, 2006. View at Publisher · View at Google Scholar · View at Scopus
  195. J. Fang, H. Nakamura, and A. K. Iyer, “Tumor-targeted induction of oxystress for cancer therapy,” Journal of Drug Targeting, vol. 15, no. 7-8, pp. 475–486, 2007. View at Publisher · View at Google Scholar · View at Scopus
  196. W. P. Tsang, S. P. Y. Chau, S. K. Kong, K. P. Fung, and T. T. Kwok, “Reactive oxygen species mediate doxorubicin induced p53-independent apoptosis,” Life Sciences, vol. 73, no. 16, pp. 2047–2058, 2003. View at Publisher · View at Google Scholar · View at Scopus
  197. M. Štěrba, O. Popelová, A. Vávrová et al., “Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection,” Antioxidants and Redox Signaling, vol. 18, no. 8, pp. 899–929, 2013. View at Publisher · View at Google Scholar · View at Scopus
  198. F. S. Carvalho, A. Burgeiro, R. Garcia, A. J. Moreno, R. A. Carvalho, and P. J. Oliveira, “Doxorubicin-induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy,” Medicinal Research Reviews, vol. 34, no. 1, pp. 106–135, 2014. View at Publisher · View at Google Scholar · View at Scopus
  199. K. A. Conklin, “Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness,” Integrative Cancer Therapies, vol. 3, no. 4, pp. 294–300, 2004. View at Publisher · View at Google Scholar · View at Scopus
  200. J. Qiao, C. Gu, W. Shang et al., “Effect of green tea on pharmacokinetics of 5-fluorouracil in rats and pharmacodynamics in human cell lines in vitro,” Food and Chemical Toxicology, vol. 49, no. 6, pp. 1410–1415, 2011. View at Publisher · View at Google Scholar · View at Scopus
  201. K. Sahin, M. Tuzcu, H. Gencoglu et al., “Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats,” Life Sciences, vol. 87, no. 7-8, pp. 240–245, 2010. View at Publisher · View at Google Scholar · View at Scopus
  202. G. I. Harisa, “Blood viscosity as a sensitive indicator for paclitaxel induced oxidative stress in human whole blood,” Saudi Pharmaceutical Journal, vol. 23, no. 1, pp. 48–54, 2015. View at Publisher · View at Google Scholar · View at Scopus
  203. T. Hadzic, N. Aykin-Burns, Y. Zhu et al., “Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress,” Free Radical Biology and Medicine, vol. 48, no. 8, pp. 1024–1033, 2010. View at Publisher · View at Google Scholar · View at Scopus
  204. T. Mizumachi, S. Suzuki, A. Naito et al., “Increased mitochondrial DNA induces acquired docetaxel resistance in head and neck cancer cells,” Oncogene, vol. 27, no. 6, pp. 831–838, 2008. View at Publisher · View at Google Scholar · View at Scopus
  205. D. L. Morse, H. Gray, C. M. Payne, and R. J. Gillies, “Docetaxel induces cell death through mitotic catastrophe in human breast cancer cells,” Molecular Cancer Therapeutics, vol. 4, no. 10, pp. 1495–1504, 2005. View at Publisher · View at Google Scholar · View at Scopus
  206. D. Cao, B. Qiao, Z. Ge, and Y. Yuan, “Amplification loop cascade for increasing caspase activity induced by docetaxel,” Journal of Cellular Biochemistry, vol. 96, no. 4, pp. 810–820, 2005. View at Publisher · View at Google Scholar · View at Scopus
  207. L. Yang, L. Zheng, Y. Tian et al., “C6 ceramide dramatically enhances docetaxel-induced growth inhibition and apoptosis in cultured breast cancer cells: a mechanism study,” Experimental Cell Research, vol. 332, no. 1, pp. 47–59, 2015. View at Publisher · View at Google Scholar
  208. L. Galluzzi, L. Senovilla, I. Vitale et al., “Molecular mechanisms of cisplatin resistance,” Oncogene, vol. 31, no. 15, pp. 1869–1883, 2012. View at Publisher · View at Google Scholar · View at Scopus
  209. J. Lee, D. H. Lim, S. Kim et al., “Phase III trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with D2 lymph node dissection: the ARTIST trial,” Journal of Clinical Oncology, vol. 30, no. 3, pp. 268–273, 2012. View at Publisher · View at Google Scholar · View at Scopus
  210. J. W. Albers, V. Chaudhry, G. Cavaletti, and R. C. Donehower, “Interventions for preventing neuropathy caused by cisplatin and related compounds,” The Cochrane Database of Systematic Reviews, vol. 3, Article ID CD005228, 2014. View at Google Scholar · View at Scopus
  211. A. S. Darvesha, B. B. Aggarwal, and A. Bishayee, “Curcumin and liver cancer: a review,” Current Pharmaceutical Biotechnology, vol. 13, no. 1, pp. 218–228, 2012. View at Publisher · View at Google Scholar · View at Scopus
  212. D. T. Dickey, L. L. Muldoon, N. D. Doolittle, D. R. Peterson, D. F. Kraemer, and E. A. Neuwelt, “Effect of N-acetylcysteine route of administration on chemoprotection against cisplatin-induced toxicity in rat models,” Cancer Chemotherapy and Pharmacology, vol. 62, no. 2, pp. 235–241, 2008. View at Publisher · View at Google Scholar · View at Scopus