In Vivo Effects of Vanadium Pentoxide and Antioxidants (Ascorbic Acid and Alpha-Tocopherol) on Apoptotic, Cytotoxic, and Genotoxic Damage in Peripheral Blood of Mice

Figure 3

Effect of antioxidants (AA and α-TOH) on the MN-PCE NIF in peripheral blood of mice at different times: (a) 24 h, (b) 48 h, and (c) 72 h after treatment with V₂O₅. Data represent “the absolute value” of the averages of MN-PCE frequencies obtained at 24, 48, and 72 h per group minus the averages of MN-PCE frequencies at 0 h per group. ANCOVA: versus control (water); versus control (corn oil); versus AA; versus α-TOH; versus AA + V₂O₅; versus α-TOH + V₂O₅. 2,000 PCE were evaluated in each mouse (5 mice per group).

(a) 24 h

(b) 48 h

(c) 72 h