In Vivo Effects of Vanadium Pentoxide and Antioxidants (Ascorbic Acid and Alpha-Tocopherol) on Apoptotic, Cytotoxic, and Genotoxic Damage in Peripheral Blood of Mice

Table 3

Evaluations at 48 h in peripheral blood of mice. Averages of early and late apoptotic and necrotic cells per group.

Group	Dose (mg/kg)		±  SD
			Early apoptotic	Late apoptotic	Necrotic
Control (water)	0	5	12.6 ± 1.7	1.2 ± 0.4	0.8 ± 0.4
Control (corn oil)	0	5	10.6 ± 2.1	1.0 ± 0.0	0.6 ± 0.5
AA	100	5	1.0 ± 0.7	33.4 ± 2.5	0.2 ± 0.4
-TOH	20	5	6.8 ± 3.2	37.8 ± 4.1	0.2 ± 0.4
V2O5	40	5	21.2 ± 5.6	40.8 ± 5.4	2.4 ± 1.3
AA + V2O5	100 + 40	5	23.8 ± 2.4	34.2 ± 1.9	0.8 ± 0.5
-TOH + V2O5	20 + 40	5	25.0 ± 3.5	41.6 ± 4.6	0.6 ± 0.5

⁢ versus control (water); versus control (corn oil); versus AA + V₂O₅; versus α-TOH + V₂O₅. Nonviable cells include apoptotic and necrotic cells. 200 nucleated cells were evaluated in each mouse (5 mice per group).