Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer
LXA4 inhibited cell invasion and decreased expression of MMP-9 and MMP-2. (a) Effect of LXA4 on cell invasion in Panc-1 cells. Cells were treated with either vehicle (methanol) or LXA4 (400 nM) and incubated for 24 hours. Then 1 × 105 cells were transferred into transwell chambers covered with Matrigel. Cultured for 48 hours, cells were stained with 0.1% crystal violet and finally observed and counted under microscope. (b) The quantified results of (a). (c) Representative western blot analysis of MMP-9 and MMP-2 in cells treated like above. versus vehicle control.
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