Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer
LXA4 downregulated MMP-9 and MMP-2 mRNA transcription. (a) Secretion of MMP-9 and MMP-2 influenced by LXA4, NAC, or FR180204. Cells were cultured with FBS-free medium for 24 hours and then MMP-9 and MMP-2 secreted into mediums normalized by cell number were tested by ELISA. (b) Western blot analysis of MMP-9 and MMP-2 in Panc-1 cells treated like above. (c) Transcription of MMP-9 and MMP-2 tested by RT-qPCR. versus vehicle control.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.