Review Article

Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System

Figure 6

Role of H2S-NO interaction in oxidative stress in CVS. The primary target of action of HNO is NADPH oxidase, which is the main culprit enzyme for endogenous synthesis of ROS in aging CVS. HNO can inhibit its activity in both sGC-cGMP dependent and independent ways. HNO is also known to strengthen anti-inflammatory response by elevating heme oxygenase-1 expression. HNO increases the diminished bioavailability of NO in oxidative stress, resulting in proper functioning of heart and blood vessels.