Long-Term Alteration of Reactive Oxygen Species Led to Multidrug Resistance in MCF-7 Cells

Figure 4

The accumulation ability of Rh123 (a) and ADM (b) was decreased by long-term treatment of H₂O₂ and GSH. MCF-7 cells were treated by replacing the culture medium every other day for 20 weeks. The accumulation ability was determined by flow cytometry. Group design and statistical analysis refer to Figure 3.

(a)

(b)