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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 7174351, 8 pages
Research Article

Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats

1Pharmacology Department, National Research Center, El Buhouth Street, Dokki, Giza 12311, Egypt
2Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
3Zoology Department, College of Science, Minia University, Minia 11432, Egypt

Received 22 October 2015; Revised 7 December 2015; Accepted 15 December 2015

Academic Editor: Ilaria Peluso

Copyright © 2016 Samir A. E. Bashandy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present study aimed to examine the protective role of Spirulina platensis (S. platensis) against arsenic-induced testicular oxidative damage in rats. Arsenic (in the form of NaAsO2 at a dose of 6.3 mg/kg body weight for 8 weeks) caused a significant accumulation of arsenic in testicular tissues as well as a decrease in the levels of testicular superoxide dismutase (SOD), catalase (CAT), reduced glutathione, and zinc. Moreover, it significantly decreased plasma testosterone, luteinizing hormone (LH), triiodothyronine (T3), and thyroxine (T4) levels and reduced sperm motility and sperm count. Arsenic (AS) led to a significant increase in testicular malondialdehyde (MDA), tumour necrosis factor alpha (TNF-α), nitric oxide (NO), and sperm abnormalities. S. platensis at a dose of 300 mg/kg was found to attenuate As-induced oxidative stress, testicular damage, and sperm abnormalities by its potent antioxidant activity. S. platensis may represent a potential therapeutic option to protect the testicular tissue from arsenic intoxication.