Alternative Interventions to Prevent Oxidative Damage following Ischemia/Reperfusion

Figure 3

Mitochondrial I/R process. Numbers indicate the four major therapeutic points. Production of ROS and RNS during I/R; depletion of scavenger enzyme systems that reduce free radical; (3) overproduction of superoxide during reperfusion; (4) release and disruption of redox signaling. See the text for a more detailed description on the physiopathological processes.