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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 7296092, 12 pages
Research Article

SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model

1Guangdong Key Laboratory of Shock and Microcirculation Research, Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China
2Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China
3Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
4Department of Critical Care Medicine, Institute of Translational Medicine, The First People’s Hospital of Chenzhou, Hunan, Chenzhou, China

Received 19 April 2016; Revised 7 September 2016; Accepted 30 October 2016

Academic Editor: Victor M. Victor

Copyright © 2016 Siqi Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplemental figure 1. Expression and activity of SIRT1 protein in glomerular epithelial cells after CLP. (a). Representative western blot of SIRT1 proteins (upper panel) and densitometric analyses (lower panel); (b) SIRT1 activity was determined using a SIRT1 Assay kit and normalized to that of the control group. Values are presented as the mean ± SEM. 11p < 0.01 vs. the control group; 22p < 0.01 vs. the vehicle group; 33p < 0.01 vs. the RSV group; 44p < 0.01 vs. the RSV+Ex527 group. n = 6. SIRT1, sirtuin; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; RSV, resveratrol; SRT, SRT1720.

  1. Supplementary Material