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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 7361613, 22 pages
http://dx.doi.org/10.1155/2016/7361613
Review Article

Overview of Alzheimer’s Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds

1Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India
2Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA

Received 12 August 2015; Accepted 5 November 2015

Academic Editor: Anne-Laure Bulteau

Copyright © 2016 Sandeep Kumar Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Alzheimer’s disease (AD) is a complex age-related neurodegenerative disease. In this review, we carefully detail amyloid-β metabolism and its role in AD. We also consider the various genetic animal models used to evaluate therapeutics. Finally, we consider the role of synthetic and plant-based compounds in therapeutics.