Overview of Alzheimer’s Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds

Figure 2

The amyloid cascade hypothesis of Alzheimer’s disease. This hypothesis represents the classic theory of the origins of AD. Both familial forms of Alzheimer’s (fAD) and later-onset forms with no known etiology (sporadic AD) lead to the production of excess Aβ₄₂. Once this toxic peptide begins to aggregate, a cascade of events is triggered that produces the biological and neurological symptoms of Alzheimer’s disease.