Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients

Table 3

Genotype and allele frequencies of the polymorphisms studied in obese and nonobese subjects.

Gene/polymorphism	Genotype	Obesity	No obesity	OR (95% CI)
TRXNIP; rs7211	CC, n (%)	350 (56.6)	523 (53.7)	Reference
	CT, n (%)	239 (38.7)	376 (38.6)	0.95 (0.7–1.2)	0.627
	TT, n (%)	29 (4.7)	75 (7.7)	0.56 (0.35–0.87)	0.012
NQO1; rs1800566	CC, n (%)	212 (34.2)	331 (33.3)	Reference
	CT, n (%)	302 (48.8)	469 (47)	1 (0.8–1.25)	0.963
	TT, n (%)	106 (17)	196 (19.7)	0.84 (0.6–1.1)	0.257
HMOX1; rs2071749	AA, n (%)	261 (40)	419 (45.7)	Reference
	AG, n (%)	306 (46.9)	378 (41.3)	1.3 (1–1.6)	0.019
	GG, n (%)	85 (13.1)	119 (13)	1.1 (0.8–1.5)	1.14
NRF2; rs2364723	CC, n (%)	194 (31)	317 (32)	Reference
	CG, n (%)	300 (48)	457 (46)	1.1 (0.85–1.35)	0.551
	GG, n (%)	131 (21)	210 (22)	0.98 (0.7–1.3)	0.899
NRF2; rs6721961	CC, n (%)	390 (63.1)	635 (63.9)	Reference
	CA, n (%)	195 (31.6)	311 (31.3)	1 (0.8–1.3)	0.853
	AA, n (%)	33 (5.3)	48 (4.8)	1.1 (0.7–1.7)	0.631

CI, confidence interval; HMOX1, heme oxygenase-1; NQO1, NAD(P)H quinone oxidoreductase 1; NRF2, Nuclear factor-erythroid 2- (NF-E2-) related factor 2; OR, odds ratio; and TXNIP, thioredoxin interacting protein.