Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 7463407, 7 pages
http://dx.doi.org/10.1155/2016/7463407
Research Article

The Responses of Tissues from the Brain, Heart, Kidney, and Liver to Resuscitation following Prolonged Cardiac Arrest by Examining Mitochondrial Respiration in Rats

1Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
2College of Liberal Arts and Sciences, Villanova University, Villanova, PA 19085, USA

Received 30 June 2015; Revised 2 September 2015; Accepted 3 September 2015

Academic Editor: Massimo Collino

Copyright © 2016 Junhwan Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. W. Roberts, J. H. Kilgannon, M. E. Chansky et al., “Multiple organ dysfunction after return of spontaneous circulation in postcardiac arrest syndrome,” Critical Care Medicine, vol. 41, no. 6, pp. 1492–1501, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Li, L. Zhang, Z. Yang et al., “Even four minutes of poor quality of CPR compromises outcome in a porcine model of prolonged cardiac arrest,” BioMed Research International, vol. 2013, Article ID 171862, 6 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Jiang, F. Meng, W. Li, L. Tong, H. Qiao, and X. Sun, “Splenectomy ameliorates acute multiple organ damage induced by liver warm ischemia reperfusion in rats,” Surgery, vol. 141, no. 1, pp. 32–40, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. L. W. Czerski, P. A. Szweda, and L. I. Szweda, “Dissociation of cytochrome c from the inner mitochondrial membrane during cardiac ischemia,” Journal of Biological Chemistry, vol. 278, no. 36, pp. 34499–34504, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. Q. Chen, S. Moghaddas, C. L. Hoppel, and E. J. Lesnefsky, “Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria,” American Journal of Physiology—Cell Physiology, vol. 294, no. 2, pp. C460–C466, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Rehncrona, L. Mela, and B. K. Siesjo, “Recovery of brain mitochondrial function in the rat after complete and incomplete cerebral ischemia,” Stroke, vol. 10, no. 4, pp. 437–446, 1979. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Iwase, “The influence of portal vein occlusion on liver mitochondria in rats after releasing biliary obstruction,” Nagoya Journal of Medical Science, vol. 48, no. 1–4, pp. 11–20, 1986. View at Google Scholar · View at Scopus
  8. B. Gonzalez-Flecha, J. C. Cutrin, and A. Boveris, “Time course and mechanism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia-reperfusion,” Journal of Clinical Investigation, vol. 91, no. 2, pp. 456–464, 1993. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Jiang, X. Fang, Y. Fu, W. Xu, L. Jiang, and Z. Huang, “Impaired cerebral mitochondrial oxidative phosphorylation function in a rat model of ventricular fibrillation and cardiopulmonary resuscitation,” BioMed Research International, vol. 2014, Article ID 192769, 9 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. R. W. Neumar, N. G. Bircher, K. M. Sim et al., “Epinephrine and sodium bicarbonate during CPR following asphyxial cardiac arrest in rats,” Resuscitation, vol. 29, no. 3, pp. 249–263, 1995. View at Publisher · View at Google Scholar · View at Scopus
  11. P. K. E. W. Ballaux, T. Gourlay, C. P. Ratnatunga, and K. M. Taylor, “A literature review of cardiopulmonary bypass models for rats,” Perfusion, vol. 14, no. 6, pp. 411–417, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Han, M. Boller, W. Guo et al., “A rodent model of emergency cardiopulmonary bypass resuscitation with different temperatures after asphyxial cardiac arrest,” Resuscitation, vol. 81, no. 1, pp. 93–99, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. H. R. Scholte, Y. Yu, J. D. Ross, I. I. Oosterkamp, A. M. C. Boonman, and H. F. M. Busch, “Rapid isolation of muscle and heart mitochondria, the lability of oxidative phosphorylation and attempts to stabilize the process in vitro by taurine, carnitine and other compounds,” Molecular and Cellular Biochemistry, vol. 174, no. 1-2, pp. 61–66, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Krahenbuhl, M. Chang, E. P. Brass, and C. L. Hoppel, “Decreased activities of ubiquinol:ferricytochrome c oxidoreductase (complex III) and ferrocytochrome c:oxygen oxidoreductase (complex IV) in liver mitochondria from rats with hydroxycobalamin[c-lactam]-induced methylmalonic aciduria,” The Journal of Biological Chemistry, vol. 266, no. 31, pp. 20998–21003, 1991. View at Google Scholar · View at Scopus
  15. J. Kim, H. Fujioka, N. L. Oleinick, and V. E. Anderson, “Photosensitization of intact heart mitochondria by the phthalocyanine Pc4: correlation of structural and functional deficits with cytochrome c release,” Free Radical Biology and Medicine, vol. 49, no. 5, pp. 726–732, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Kim, T. Yin, M. Yin et al., “Examination of physiological function and biochemical disorders in a rat model of prolonged asphyxia-induced cardiac arrest followed by cardio pulmonary bypass resuscitation,” PLoS ONE, vol. 9, no. 11, Article ID e112012, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Kim, J. Lampe, T. Yin, K. Shinozaki, and L. Becker, “Phospholipid alterations in the brain and heart in a rat model of asphyxia-induced cardiac arrest and cardiopulmonary bypass resuscitation,” Molecular and Cellular Biochemistry, 2015. View at Publisher · View at Google Scholar
  18. V. Borutaite, A. Toleikis, and G. C. Brown, “In the eye of the storm: mitochondrial damage during heart and brain ischaemia,” The FEBS Journal, vol. 280, no. 20, pp. 4999–5014, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. N. R. Sims and H. Muyderman, “Mitochondria, oxidative metabolism and cell death in stroke,” Biochimica et Biophysica Acta, vol. 1802, no. 1, pp. 80–91, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Dezfulian, S. Shiva, A. Alekseyenko et al., “Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I,” Circulation, vol. 120, no. 10, pp. 897–905, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. S. T. Yeh, H.-L. Lee, S. E. Aune, C.-L. Chen, Y.-R. Chen, and M. G. Angelos, “Preservation of mitochondrial function with cardiopulmonary resuscitation in prolonged cardiac arrest in rats,” Journal of Molecular and Cellular Cardiology, vol. 47, no. 6, pp. 789–797, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. B. C. White, J. F. Hildebrandt, A. T. Evans et al., “Prolonged cardiac arrest and resuscitation in dogs: brain mitochondrial function with different artificial perfusion methods,” Annals of Emergency Medicine, vol. 14, no. 5, pp. 383–388, 1985. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Pan, A.-A. Konstas, B. Bateman, G. A. Ortolano, and J. Pile-Spellman, “Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies,” Neuroradiology, vol. 49, no. 2, pp. 93–102, 2007. View at Publisher · View at Google Scholar · View at Scopus