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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 7520231, 8 pages
http://dx.doi.org/10.1155/2016/7520231
Research Article

Oxidative Stress Biomarkers and Left Ventricular Hypertrophy in Children with Chronic Kidney Disease

1Dialysis Unit, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland
2Department of Pediatrics, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland
3Department of Clinical Biochemistry, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland
4Department of Pediatric Cardiology, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland
5I Department of Cardiology, Interventional Cardiology and Hypertension, Jagiellonian University Medical College, 17 Kopernika Street, 31-501 Krakow, Poland

Received 2 October 2015; Revised 28 November 2015; Accepted 13 December 2015

Academic Editor: Gerasimos Sykiotis

Copyright © 2016 Dorota Drożdż et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cardiovascular diseases remain the most frequent cause of morbidity and mortality in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between oxidative stress biomarkers and cardiovascular risk factors and left ventricular hypertrophy in children with CKD. Material and Methods. The studied group consisted of 65 patients aged 1.4–18.6 (mean 11.2) years with stages 1 to 5 CKD. Serum oxidized low-density lipoprotein (oxLDL), protein carbonyl group, creatinine, cystatin C, albumin, lipids, high-sensitivity C-reactive protein, intercellular adhesion molecule-1, insulin, plasma renin activity, and aldosterone levels were measured. Patients were divided into groups depending on CKD stage. Anthropometric measurements, ambulatory blood pressure (BP) measurements, and echocardiography with left ventricular mass (LVM) calculation were performed. Results. Serum oxLDL strongly correlated with creatinine (; ), cystatin C (; ), total cholesterol (; ), triglycerides (; ), low-density lipoprotein concentrations (; ), and 24 hour BP values of systolic (; ), diastolic (; ), and mean arterial pressure (; ). A significant correlation between oxLDL levels and LVM -scores (; ) was found. Conclusions. Hypertension and dyslipidemia correlated with lipid oxidation in children with CKD. oxLDLs seem to be valuable markers of oxidative stress in CKD patients, correlating with left ventricular hypertrophy.