Identification of MicroRNAs Involved in Growth Arrest and Apoptosis in Hydrogen Peroxide-Treated Human Hepatocellular Carcinoma Cell Line HepG2

Figure 5

Changes in miRNAs expression profiles in H₂O₂ treated HepG2 cells. Total RNA was extracted from control group and HepG2 cells treated with 600 or 30 μM H₂O₂ for 24 h. miRNAs microarray was performed as described in Materials and Methods. (a) High concentration versus control group, changes in miRNAs expression > 2-fold, and < 0.05 are illustrated by heat map. Green indicates a relatively low expression and red indicates a relatively high expression. (b) Low concentration versus control group, changes in miRNAs expression > 1.2-fold, and < 0.5 are illustrated by heat map. High: high concentration of H₂O₂ group, 600 μM; Con: control group; Low: low concentration of H₂O₂ group, 30 μM.

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