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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 7589813, 13 pages
http://dx.doi.org/10.1155/2016/7589813
Research Article

Resveratrol Enhances Autophagic Flux and Promotes Ox-LDL Degradation in HUVECs via Upregulation of SIRT1

1Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
2Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
3Department of Endocrinology, Ningbo Number 2 Hospital, Ningbo 315000, China
4Institute of Neuroscience, Soochow University, Suzhou 215123, China

Received 2 November 2015; Revised 9 February 2016; Accepted 21 February 2016

Academic Editor: Junhwan Kim

Copyright © 2016 Yanlin Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M.-H. Cho, K. Cho, H.-J. Kang et al., “Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome,” Autophagy, vol. 10, no. 10, pp. 1761–1775, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Singh, S. Kaushik, Y. Wang et al., “Autophagy regulates lipid metabolism,” Nature, vol. 458, no. 7242, pp. 1131–1135, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Ivanova, U. Repnik, L. Boji, A. Petelin, V. Turk, and B. Turk, “Chapter nine lysosomes in apoptosis,” Methods in Enzymology, vol. 442, pp. 183–199, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Nishida, S. Arakawa, K. Fujitani et al., “Discovery of Atg5/Atg7-independent alternative macroautophagy,” Nature, vol. 461, no. 7264, pp. 654–658, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. F. Wu, H.-D. Xu, J.-J. Guan et al., “Rotenone impairs autophagic flux and lysosomal functions in Parkinson's disease,” Neuroscience, vol. 284, pp. 900–911, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. C. T. Chu, “Autophagic stress in neuronal injury and disease,” Journal of Neuropathology and Experimental Neurology, vol. 65, no. 5, pp. 423–432, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Muller, R. Salvayre, A. Nègre-Salvayre, and C. Vindis, “Oxidized LDLs trigger endoplasmic reticulum stress and autophagy: prevention by HDLs,” Autophagy, vol. 7, no. 5, pp. 541–543, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. W. Martinet and G. R. Y. De Meyer, “Autophagy in atherosclerosis,” Current Atherosclerosis Reports, vol. 10, no. 3, pp. 216–223, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. Y.-L. Zhang, Y.-J. Cao, X. Zhang et al., “The autophagy-lysosome pathway: a novel mechanism involved in the processing of oxidized ldl in human vascular endothelial cells,” Biochemical and Biophysical Research Communications, vol. 394, no. 2, pp. 377–382, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Pervaiz and A. L. Holme, “Resveratrol: its biologic targets and functional activity,” Antioxidants and Redox Signaling, vol. 11, no. 11, pp. 2851–2897, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Hariharan, Y. Maejima, J. Nakae, J. Paik, R. A. Depinho, and J. Sadoshima, “Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes,” Circulation Research, vol. 107, no. 12, pp. 1470–1482, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. B. Wang, Q. Yang, Y.-Y. Sun et al., “Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice,” Journal of Cellular and Molecular Medicine, vol. 18, no. 8, pp. 1599–1611, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Guo, Y. Chen, L. Liao, and W. Wu, “Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK/SIRT1 pathway,” Cardiovascular Drugs and Therapy, vol. 27, no. 3, pp. 189–198, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. H.-C. Ou, F.-P. Chou, H.-M. Sheen, T.-M. Lin, C.-H. Yang, and W. Huey-Herng Sheu, “Resveratrol, a polyphenolic compound in red wine, protects against oxidized LDL-induced cytotoxicity in endothelial cells,” Clinica Chimica Acta, vol. 364, no. 1-2, pp. 196–204, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. M.-L. Chen, L. Yi, X. Jin et al., “Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway,” Autophagy, vol. 9, no. 12, pp. 2033–2045, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Mariño, M. Niso-Santano, E. H. Baehrecke, and G. Kroemer, “Self-consumption: the interplay of autophagy and apoptosis,” Nature Reviews Molecular Cell Biology, vol. 15, no. 2, pp. 81–94, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Kimura, T. Noda, and T. Yoshimori, “Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3,” Autophagy, vol. 3, no. 5, pp. 452–460, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. K.-L. Tsai, L.-H. Chen, S.-H. Chiou et al., “Coenzyme Q10 suppresses oxLDL-induced endothelial oxidative injuries by the modulation of LOX-1-mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway,” Molecular Nutrition and Food Research, vol. 55, supplement 2, pp. S227–S240, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Rajagopalan, E. C. Somers, R. D. Brook et al., “Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity,” Blood, vol. 103, no. 10, pp. 3677–3683, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Durand, A. Scoazec, A. Lafont et al., “In vivo induction of endothelial apoptosis leads to vessel thrombosis and endothelial denudation: a clue to the understanding of the mechanisms of thrombotic plaque erosion,” Circulation, vol. 109, no. 21, pp. 2503–2506, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Li and U. Forstermann, “Resveratrol: a multifunctional compound improving endothelial function,” Cardiovascular Drugs and Therapy, vol. 23, no. 6, pp. 425–429, 2009. View at Publisher · View at Google Scholar
  22. C. A. Schmitt, E. H. Heiss, and V. M. Dirsch, “Effect of resveratrol on endothelial cell function: molecular mechanisms,” BioFactors, vol. 36, no. 5, pp. 342–349, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Sawamura, N. Kume, T. Aoyama et al., “An endothelial receptor for oxidized low-density lipoprotein,” Nature, vol. 386, no. 6620, pp. 73–77, 1997. View at Publisher · View at Google Scholar · View at Scopus
  24. B. Huang, M. Jin, H. Yan et al., “Simvastatin enhances oxidized-low density lipoprotein-induced macrophage autophagy and attenuates lipid aggregation,” Molecular Medicine Reports, vol. 11, no. 2, pp. 1093–1098, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. B.-H. Li, Y.-W. Yin, Y. Liu et al., “TRPV1 activation impedes foam cell formation by inducing autophagy in oxLDL-treated vascular smooth muscle cells,” Cell Death and Disease, vol. 5, no. 4, Article ID e1182, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. K. H. Kim and M.-S. Lee, “Autophagy—a key player in cellular and body metabolism,” Nature Reviews Endocrinology, vol. 10, no. 6, pp. 322–337, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. X. Fan, J. Wang, J. Hou et al., “Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway,” Journal of Translational Medicine, vol. 13, no. 1, article 92, 2015. View at Publisher · View at Google Scholar
  28. N. Peng, N. Meng, S. Wang et al., “An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice,” Scientific Reports, vol. 4, article 5519, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. H. H. Lin, “In vitro and in vivo atheroprotective effects of gossypetin against endothelial cell injury by induction of autophagy,” Chemical Research in Toxicology, vol. 28, pp. 202–215, 2015. View at Google Scholar
  30. R. Emanuel, I. Sergin, S. Bhattacharya et al., “Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, no. 9, pp. 1942–1952, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. G. Las, S. B. Serada, J. D. Wikstrom, G. Twig, and O. S. Shirihai, “Fatty acids suppress autophagic turnover in β-cells,” The Journal of Biological Chemistry, vol. 286, no. 49, pp. 42534–42544, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Lougheed, H. F. Zhang, and U. P. Steinbrecher, “Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages,” The Journal of Biological Chemistry, vol. 266, no. 22, pp. 14519–14525, 1991. View at Google Scholar · View at Scopus
  33. G. Hoppe, J. O'Neil, and H. F. Hoff, “Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages,” The Journal of Clinical Investigation, vol. 94, no. 4, pp. 1506–1512, 1994. View at Publisher · View at Google Scholar · View at Scopus
  34. G. Hoppe, J. O'Neil, H. F. Hoff, and J. Sears, “Products of lipid peroxidation induce missorting of the principal lysosomal protease in retinal pigment epithelium,” Biochimica et Biophysica Acta—Molecular Basis of Disease, vol. 1689, no. 1, pp. 33–41, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Chen, T. Masaki, and T. Sawamura, “LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis,” Pharmacology and Therapeutics, vol. 95, no. 1, pp. 89–100, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. Z. Ding, S. Liu, C. Sun et al., “Concentration polarization of ox-LDL activates autophagy and apoptosis via regulating LOX-1 expression,” Scientific Reports, vol. 3, article 2091, 2013. View at Publisher · View at Google Scholar
  37. X. Jin, M. Chen, L. Yi et al., “Delphinidin-3-glucoside protects human umbilical vein endothelial cells against oxidized low-density lipoprotein-induced injury by autophagy upregulation via the AMPK/SIRT1 signaling pathway,” Molecular Nutrition and Food Research, vol. 58, no. 10, pp. 1941–1951, 2014. View at Publisher · View at Google Scholar · View at Scopus
  38. Y. M. Song, Y. Lee, J. Kim et al., “Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway,” Autophagy, vol. 11, no. 1, pp. 46–59, 2014. View at Publisher · View at Google Scholar
  39. E. Morselli, M. C. Maiuri, M. Markaki et al., “Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy,” Cell Death and Disease, vol. 1, article e10, 2010. View at Publisher · View at Google Scholar · View at Scopus