Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway

Figure 1

SFN administration protects against cerulein-induced AP in mice. The administration of SFN (5 mg/kg) in mice significantly attenuated the increase of serum amylase activity (a), pancreatic water content ((b) indicator of edema), pancreatic MPO activity ((c) indicator of leukocyte infiltration), and pancreatic acinar cell necrosis ((d) morphological examination), induced by cerulein. Values are expressed as mean ± SEM. and when cerulein-induced mice were compared with control mice. and when SFN-treated AP mice were compared to cerulein-induced mice.

(a)

(b)

(c)

(d)