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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 7891574, 10 pages
http://dx.doi.org/10.1155/2016/7891574
Review Article

Oxidative Stress and Liver Cancer: Etiology and Therapeutic Targets

1Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China
2Department of Plastic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China
3Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China

Received 4 July 2016; Revised 30 September 2016; Accepted 18 October 2016

Academic Editor: Pablo Muriel

Copyright © 2016 Zhanpeng Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Accumulating evidence has indicated that oxidative stress (OS) is associated with the development of hepatocellular carcinoma (HCC). However, the mechanisms remain largely unknown. Normally, OS occurs when the body receives any danger signal—from either an internal or external source—and further induces DNA oxidative damage and abnormal protein expression, placing the body into a state of vulnerability to the development of various diseases such as cancer. There are many factors involved in liver carcinogenesis, including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, alcohol abuse, and nonalcoholic fatty liver disease (NAFLD). The relationship between OS and HCC has recently been attracting increasing attention. Therefore, elucidation of the impact of OS on the development of liver carcinogenesis is very important for the prevention and treatment of liver cancer. This review focuses mainly on the relationship between OS and the development of HCC from the perspective of cellular and molecular mechanisms and the etiology and therapeutic targets of HCC.