Oxidative Stress and Liver Cancer: Etiology and Therapeutic Targets

Table 2

Summary of antioxidant treatment targets in HCC therapy.

Ref number	Antioxidant treatment	Targets	Pros/cons HCC
[67]	Curcuminoids	Glutathione (GSH)↑, P450↓	Cons
[68, 69]	Ascorbic acid, lipoic acid; quercetin, mitoquinone, ebselen	GSH	Cons
[68, 69]	Resveratrol	GSH↑, ROS	Cons
[70–72]	Vitamin E	HBV↓, TGF-β↓	Cons
[73]	Phlebotomy	Fe^2+	Cons
[74–76]	Metformin	AMPK↑, Nrf2↑, IL-6↑,; hemeoxygenase-1 (HO-1)↑	Cons
[77, 78]	5-Aminoimidazole-4-carboxamide-1-b-ribofuranoside (AICAR)	Nrf2↑	Cons
[79–81]	L-Carnitine	Mitochondria	Cons