Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart
Table 1
Effect of astragalin on cardiac function in rats subjected to I/R (values are presented as mean SD, ).
Physical index
Reperfusion (%)
15 min
30 min
45 min
LVDP
Control
97.41 ± 4.49
94.89 ± 6.04
94.11 ± 6.85
I/R
40.93 ± 3.83
47.61 ± 4.17
49.19 ± 2.44
5 µmol/L astragalin
50.16 ± 5.25
64.82 ± 5.30
62.23 ± 6.87
10 µmol/L astragalin
84.97 ± 3.53
81.67 ± 6.37
79.92 ± 5.82
20 µmol/L astragalin
68.88 ± 5.24
66.45 ± 4.19
63.15 ± 3.53
Control
104.18 ± 13.85
103.12 ± 14.17
103.03 ± 11.86
I/R
41.90 ± 4.10
52.54 ± 4.30
52.17 ± 4.86
5 µmol/L astragalin
52.51 ± 5.34
60.79 ± 4.12
63.34 ± 5.13
10 µmol/L astragalin
83.70 ± 3.46
85.05 ± 4.96
80.58 ± 5.78
20 µmol/L astragalin
67.96 ± 3.07
65.62 ± 4.68
62.38 ± 4.67
Control
96.85 ± 3.61
94.96 ± 2.94
94.17 ± 0.94
I/R
49.56 ± 7.51
56.98 ± 3.91
56.10 ± 5.80
5 µmol/L astragalin
59.15 ± 3.36
56.30 ± 5.61
57.52 ± 5.39
10 µmol/L astragalin
85.77 ± 4.71
84.49 ± 6.86
81.17 ± 7.51
20 µmol/L astragalin
64.72 ± 4.19
63.34 ± 4.05
60.69 ± 4.35
CF
Control
107.69 ± 4.35
108.15 ± 4.94
106.47 ± 7.19
I/R
57.69 ± 4.74
58.15 ± 4.16
56.47 ± 2.53
5 µmol/L astragalin
63.60 ± 3.65
66.54 ± 3.22
68.62 ± 5.79
10 µmol/L astragalin
108.36 ± 7.41
108.15 ± 10.98
106.84 ± 13.35
20 µmol/L astragalin
72.11 ± 7.88
70.19 ± 1.88
70.20 ± 4.46
HR
Control
98.42 ± 2.62
98.67 ± 4.24
100.34 ± 2.61
I/R
84.10 ± 8.58
86.39 ± 4.67
86.79 ± 6.99
5 µmol/L astragalin
96.75 ± 3.27
94.67 ± 2.78
93.67 ± 2.41
10 µmol/L astragalin
94.04 ± 1.66
95.45 ± 5.04
89.27 ± 8.24
20 µmol/L astragalin
89.04 ± 6.48
90.25 ± 6.22
91.14 ± 3.14
Left ventricular developed pressure (LVDP), the maximum up rate of left ventricular pressure (), the maximum down rate of left ventricular pressure (), coronary flow (CF), and heart rate (HR). and compared with the control group; and compared with the I/R group.
