Research Article

Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells

Figure 1

Effect of Hericium erinaceus (HE) and/or TNF-α on cell viability of human endothelial (EA.hy926) cells. (a) Cells were treated with HE (50–300 μg/mL) for 4 h. (b) Cells were pretreated with HE (50–300 μg/mL) for 4 h and then stimulated with TNF-α (10 ng/mL) for 24 h. Cell viability (%) was determined by MTT assay. Results are presented as mean ± SD of three independent assays. indicates significant difference compared to control, and indicates significant difference compared to TNF-α alone treatment.