AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer’s Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons
AP39 alleviated the brain atrophy of APP/PS1 mice as observed by brain magnetic resonance imaging (MRI). Brain MRI data were collected at different coronal and axial sections in 12-month-old mice receiving different treatments. Notes: panels (a), (c), and (e) show coronal sections, and panels (b), (d), and (f) show axial sections. The highlighted white regions indicate cerebrospinal fluid (CSF) in the ventricle, and the hippocampus is adjacent to the ventricle. Representative images from brain MRI depict slices of the T2-weighted morphologic images of 12-month-old WT mice treated with water (a)-(b) or AD mice treated with water (c)-(d) or AP39 (e)-(f). (g) ADC value determination of the mouse brains.