Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins

Figure 1

Selected glycerophospholipids (PLs) which will be relevant for this review. Note that phosphatidylcholine (PC) and ethanolamine (PE) are zwitterionic lipids, while PS is an example of a negatively charged PL. PLs in biological samples often contain a saturated fatty acyl residue in sn-1 position, while that in sn-2 position is normally unsaturated. Ether PL are characterized either by an alkenyl or alkyl linkage in sn-1 position at the glycerol backbone. Alkenyl ether lipids are often called “plasmalogens.”