Oxidative Medicine and Cellular Longevity / 2016 / Article / Fig 4

Review Article

Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins

Figure 4

Overview of the released reactive oxygen species (ROS) and antimicrobial enzymes by an activated neutrophil during the inflammatory process in an inflamed joint. Due to the release of highly toxic ROS, most of them (including HOCl) do not discriminate between microbial and “healthy” targets, leading to an uncontrolled oxidation of all biomolecules and a persistent inflammation (reprinted from Schiller et al. [25], with permission from Elsevier).

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