The Tumorigenic Roles of the Cellular REDOX Regulatory Systems

Figure 3

Antioxidant systems in cancer. Cancer cells undergo REDOX adaptation to survive and proliferate in an environment with increasing oxidative stress. Regulation of ROS levels by the cellular antioxidant systems is crucial to maintain a proliferative and mutagenic phenotype (associated with low/moderate levels of ROS) and avoid apoptosis or senescence (associated with high levels of ROS).