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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 8473242, 9 pages
http://dx.doi.org/10.1155/2016/8473242
Research Article

Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage

1Department of Molecular Biomedicine, CINVESTAV, Avenida IPN 2508, San Pedro Zacatenco, 07360 Mexico City, DF, Mexico
2Department of Infectomics and Molecular Pathogenesis, CINVESTAV, Avenida IPN 2508, San Pedro Zacatenco, 07360 Mexico City, DF, Mexico
3Department of Pharmacology, National Cardiology Institute “Ignacio Chávez”, 14080 Mexico City, DF, Mexico
4Department of Physiology, Biophysics and Neurosciences, CINVESTAV, Avenida IPN 2508, San Pedro Zacatenco, 07360 Mexico City, DF, Mexico

Received 24 October 2015; Accepted 1 December 2015

Academic Editor: Noriko Noguchi

Copyright © 2016 Hilda Vargas Robles et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn’s disease (CD) are multifactorial, relapsing disorders of the gastrointestinal tract. However, the etiology is still poorly understood but involves altered immune responses, epithelial dysfunction, environmental factors, and nutrition. Recently, we have shown that the diet supplement corabion has cardioprotective effects due to reduction of oxidative stress and inflammation. Since oxidative stress and inflammation are also prominent risk factors in IBD, we speculated that corabion also has beneficial effects on experimental colitis. Colitis was induced in male mice by administration of 3.5% (w/v) dextran sulfate sodium (DSS) in drinking water for a period of 3 or 7 days with or without daily gavage feeding of corabion consisting of vitamin C, vitamin E, L-arginine, and eicosapentaenoic and docosahexaenoic acid. We found that corabion administration attenuated DSS-induced colon shortening, tissue damage, and disease activity index during the onset of colitis. Mechanistically, these effects could be explained by reduced neutrophil recruitment, oxidative stress, production of proinflammatory cytokines, and internalization of the junctional proteins ZO-1 and E-cadherin leading to less edema formation. Thus, corabion may be a useful diet supplement for the management of chronic inflammatory intestinal disorders such as IBD.