Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 8474303, 10 pages
http://dx.doi.org/10.1155/2016/8474303
Research Article

Parkin Protects against Oxygen-Glucose Deprivation/Reperfusion Insult by Promoting Drp1 Degradation

1Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
2Department of Neurology, The Second People’s Hospital of Hunan Province, Changsha, Hunan 410007, China
3National Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410078, China

Received 27 February 2016; Revised 13 June 2016; Accepted 11 July 2016

Academic Editor: Maria G. Isaguliants

Copyright © 2016 Jiayu Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S.-H. Baek, A. R. Noh, K.-A. Kim et al., “Modulation of mitochondrial function and autophagy mediates carnosine neuroprotection against ischemic brain damage,” Stroke, vol. 45, no. 8, pp. 2438–2443, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. D. N. Silachev, E. Y. Plotnikov, L. D. Zorova et al., “Neuroprotective effects of mitochondria-targeted plastoquinone and thymoquinone in a rat model of brain ischemia/reperfusion injury,” Molecules, vol. 20, no. 8, pp. 14487–14503, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Buhlman, M. Damiano, G. Bertolin et al., “Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance,” Biochimica et Biophysica Acta (BBA)—Molecular Cell Research, vol. 1843, no. 9, pp. 2012–2026, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Kageyama, M. Hoshijima, K. Seo et al., “Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain,” EMBO Journal, vol. 33, no. 23, pp. 2798–2813, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. H. J. Kim, M. R. Shaker, B. Cho et al., “Dynamin-related protein 1 controls the migration and neuronal differentiation of subventricular zone-derived neural progenitor cells,” Scientific Reports, vol. 5, Article ID 15962, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Li, P. Wang, J. Wei et al., “Inhibition of Drp1 by Mdivi-1 attenuates cerebral ischemic injury via inhibition of the mitochondria-dependent apoptotic pathway after cardiac arrest,” Neuroscience, vol. 311, pp. 67–74, 2015. View at Publisher · View at Google Scholar
  7. F. Kamp, N. Exner, A. K. Lutz et al., “Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1,” The EMBO Journal, vol. 29, no. 20, pp. 3571–3589, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Wang, P. Song, L. Du et al., “Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease,” The Journal of Biological Chemistry, vol. 286, no. 13, pp. 11649–11658, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Takamura, Y. Koyama, S. Matsuzaki et al., “TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression,” PLoS ONE, vol. 7, no. 12, Article ID e51912, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Di, Y.-L. He, T. Zhao et al., “Methylene blue reduces acute cerebral ischemic injury via the induction of mitophagy,” Molecular Medicine, vol. 21, pp. 420–429, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Y. Kim, M. S. Shim, K.-Y. Kim, R. N. Weinreb, L. A. Wheeler, and W.-K. Ju, “Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury,” Cell Death and Disease, vol. 5, no. 3, Article ID e1105, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Zeng, J. Tan, W. Lu, and Z. Hu, “Blockade of Ser16-Hsp20 phosphorylation attenuates neuroprotection dependent upon Bcl-2 and bax,” Current Neurovascular Research, vol. 10, no. 3, pp. 208–215, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. X.-M. Zhang, L. Zhang, G. Wang et al., “Suppression of mitochondrial fission in experimental cerebral ischemia: the potential neuroprotective target of p38 MAPK inhibition,” Neurochemistry International, vol. 90, pp. 1–8, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Tamura, K. Itoh, and H. Sesaki, “SnapShot: mitochondrial dynamics,” Cell, vol. 145, no. 7, pp. 1158–1158.e1, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Grohm, S.-W. Kim, U. Mamrak et al., “Inhibition of Drp1 provides neuroprotection in vitro and in vivo,” Cell Death and Differentiation, vol. 19, no. 9, pp. 1446–1458, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. H. Shimura, N. Hattori, S.-I. Kubo et al., “Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase,” Nature Genetics, vol. 25, no. 3, pp. 302–305, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. S.-H. Cha, Y. R. Choi, C.-H. Heo et al., “Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson's disease,” Molecular Neurodegeneration, vol. 10, article 63, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Puschmann, “Monogenic Parkinson's disease and parkinsonism: clinical phenotypes and frequencies of known mutations,” Parkinsonism and Related Disorders, vol. 19, no. 4, pp. 407–415, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Kitada, S. Asakawa, N. Hattori et al., “Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism,” Nature, vol. 392, no. 6676, pp. 605–608, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Mengesdorf, P. H. Jensen, G. Mies, C. Aufenberg, and W. Paschen, “Down-regulation of parkin protein in transient focal cerebral ischemia: a link between stroke and degenerative disease?” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 23, pp. 15042–15047, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Cook, C. Stetler, and L. Petrucelli, “Disruption of protein quality control in Parkinson's disease,” Cold Spring Harbor Perspectives in Medicine, vol. 2, no. 5, Article ID a009423, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. W. Zhao, M. Bonem, C. McWhite, J. J. Silberg, and L. Segatori, “Sensitive detection of proteasomal activation using the Deg-On mammalian synthetic gene circuit,” Nature Communications, vol. 5, article 3612, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. N. C. Chan and D. C. Chan, “Parkin uses the UPS to ship off dysfunctional mitochondria,” Autophagy, vol. 7, no. 7, pp. 771–772, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. P. H. Reddy, T. P. Reddy, M. Manczak, M. J. Calkins, U. Shirendeb, and P. Mao, “Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases,” Brain Research Reviews, vol. 67, no. 1-2, pp. 103–118, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Brooks, Q. Wei, S.-G. Cho, and Z. Dong, “Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models,” The Journal of Clinical Investigation, vol. 119, no. 5, pp. 1275–1285, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. S.-B. Ong, S. Subrayan, S. Y. Lim, D. M. Yellon, S. M. Davidson, and D. J. Hausenloy, “Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury,” Circulation, vol. 121, no. 18, pp. 2012–2022, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. S. W. Park, K.-Y. Kim, J. D. Lindsey et al., “A selective inhibitor of Drp1, Mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina,” Investigative Ophthalmology and Visual Science, vol. 52, no. 5, pp. 2837–2843, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. Y.-X. Zhao, M. Cui, S.-F. Chen, Q. Dong, and X.-Y. Liu, “Amelioration of ischemic mitochondrial injury and bax-dependent outer membrane permeabilization by Mdivi-1,” CNS Neuroscience and Therapeutics, vol. 20, no. 6, pp. 528–538, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Yamamori, S. Ike, T. Bo et al., “Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation,” Molecular Biology of the Cell, vol. 26, no. 25, pp. 4607–4617, 2015. View at Publisher · View at Google Scholar · View at Scopus
  30. J. H. Park, J. Ko, J. Hwang, and H. C. Koh, “Dynamin-related protein 1 mediates mitochondria-dependent apoptosis in chlorpyrifos-treated SH-SY5Y cells,” NeuroToxicology, vol. 51, pp. 145–157, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Yung, D. Sha, L. Li, and L.-S. Chin, “Parkin protects against misfolded SOD1 toxicity by promoting its aggresome formation and autophagic clearance,” Molecular Neurobiology, 2015. View at Publisher · View at Google Scholar · View at Scopus
  32. L. Petrucelli, C. O'Farrell, P. J. Lockhart et al., “Parkin protects against the toxicity associated with mutant α-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons,” Neuron, vol. 36, no. 6, pp. 1007–1019, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. K. M. Rosen, C. E.-H. Moussa, H.-K. Lee et al., “Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function,” Journal of Neuroscience Research, vol. 88, no. 1, pp. 167–178, 2010. View at Publisher · View at Google Scholar · View at Scopus