Research Article

Nephroprotective Effects of N-Acetylcysteine Amide against Contrast-Induced Nephropathy through Upregulating Thioredoxin-1, Inhibiting ASK1/p38MAPK Pathway, and Suppressing Oxidative Stress and Apoptosis in Rats

Figure 3

NACA inhibited CM-induced indicators of oxidative stress in kidney. Exposure to CM significantly attenuated renal SOD (a) and GSH levels and increased MDA (b) levels. Pretreatment with NAC or NACA blocked the CIN-induced changes. Figures are representative of 5 to 8 rats in each group. The values are means ± SD (). versus CON, versus CON, versus CIN, and versus CIN+NAC.
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