Induction of Expression of p75 Neurotrophin Receptor Intracellular Domain Does Not Induce Expression or Enhance Activity of Mitochondrial Complex II

Table 1

Percent cell survival (MTS assay) of p75ICD- or mock-transfected NIH 3T3 cells treated with H₂O₂ and p75NTR- or mock-transfected SH-EP1 cells treated with fenretinide. In both cases, note the potentiation of the cytocidal effects of oxidative stress by induced p75NTR or p75ICD. Results represent mean ± SEM; determinations at each concentration.

[H2O2]	0 M	200 M	600 M	1000 M
NIH 3T3 cells, p75ICD-transfected
NIH 3T3 cells, mock-transfected
[Fenretinide]	0 M	6 M	12 M	18 M
SH-EP1 cells, p75NTR-transfected
SH-EP1 cells, mock-transfected