Effects of Hyperoxia on Oxygen-Related Inflammation with a Focus on Obesity

Table 1

Results of the responses (mRNA, protein, and ROS production) to different oxygen exposures in different experimental models.

Gene	Model/tissue	Treatment	Duration	mRNA	Prot.	Authors
Angptl4	3T3-L1/adipocyte culture	95% O2	24 h	↓	ND	[46]
Hif-1α	3T3-L1/adipocyte culture	95% O2	24 h	ns	ND	[46]
	Male C56BL/6J mice/brain	50% O2	1 week	ns	ND	[112]
	Sprague-Dawley rat/brain with IH damage	NBOT/HBOT	2 h	ND	↑↑/↑	[86]
Il-1	Sprague-Dawley rat/lung	90% O2	10 h, on postnatal day 14	ND	↑	[113]
	Human/alveolar macrophages primary culture (ILD)	95% O2	48 h	↓	ND	[75]
	C57BL/6J mice/lung	>95% O2	3 days	↑	ND	[114]
Il-6	Sprague-Dawley rat/lung	90% O2	10 h, on postnatal day 14	ND	↑	[113]
	3T3-L1/adipocyte culture	95% O2	24 h	↑	ND	[46]
	Male C57BL/6J WT mice and db/db mice/BAL	100% O2	84 h	ND	↑	[115]
	Human/alveolar macrophages primary culture (ILD)	95% O2	48 h	↓	ND	[75]
	C57BL/6J mice/lung	>95% O2	3 days	ND	↓	[114]
Il-8	Human/UVEC culture with chronic wound	97.5% O2	90′	↓	↓	[109]
	Human/alveolar macrophages primary culture (ILD)	95% O2	48 h	↑	ND	[75]
Leptin	3T3-L1/adipocyte culture	95% O2	24 h	ns	ND	[46]
	Male C57BL/6J WT mice and db/db mice/BAL	100% O2	84 h	ND	↑	[115]
	Female C57BL/6 ob/ob mice/adipose tissue	100% O2	72 h	↑	ND	[116]
Tnf-α	Sprague-Dawley rat/lung	90% O2	10 h, on postnatal day 14	ND	↑	[113]
	Male C57BL/6J WT mice and db/db mice/BAL	100% O2	84 h	ND	↑	[115]
	Female 57BL/6 ob/ob mice/adipose tissue	100% O2	72 h	↓	ns	[116]
	Human/alveolar macrophages primary culture (ILD)	95% O2	48 h	↓	ND	[75]
	Sprague-Dawley rat/lung macrophages primary culture	100% O2	90′	ND	↑	[117]
	C57BL/6J mice/lung	>95% O2	3 days	ND	↑	[114]
Vegf	Sprague-Dawley rat/lung	90% O2	10 h, on postnatal day 14	ND	↓	[113]
	Male C56BL/6J mice/brain	50% O2	1 week	↓	ND	[112]
	Sprague-Dawley rat/wound fluid	100% O2	90′ twice daily for 7 days	ND	↑	[94]
	Sprague-Dawley rat/liver	95% O2	2 weeks, newborn	ND	↓	[118]
ROS	3T3-L1/adipocyte culture	95% O2	24 h	↑		[46]
	Sprague-Dawley rat/carotid body and PG/NG complex	95% O2	4 h	↑		[119]
	Male Sprague-Dawley rats/lung capillary endothelial cells	70% O2	90′	↑		[120]
	C57BL/6J mice/liver with ischemia	60% O2	24 h	↑		[121]

Angptl4: Angiopoietin-like 4; Hif-1α: hypoxia-inducible factor-1α; Il-1: Interleukin-1; Il-6: Interleukin-6; Il-8: Interleukin-8; Tnf-α: tumor necrosis factor-α; Vegf: vascular endothelial growth factor; ROS: reactive oxygen species; BAL: bronchoalveolar lavage; CIH: chronic intermittent hypoxia; ILD: interstitial lung disease; UVEC: umbilical vein endothelial cells; ND: no data; ns: no significant difference detected.