Research Article

PAN-811 Blocks Chemotherapy Drug-Induced In Vitro Neurotoxicity, While Not Affecting Suppression of Cancer Cell Growth

Figure 4

No interference of PAN-811⋅Cl⋅H2O with anticancer drug-induced cytotoxicity to mouse cancer cell line BNLT3. (a)–(c) Phase contrast photographs for BNLT3 cells that were treated without or with 10 μM PAN-811⋅Cl⋅H2O and insulted with 100 μM MTX, 25 μM 5-FU, or 3.5 μM CDDP for 3 days, respectively (bar = 50 μm). (d)–(f) MTS analysis corresponding to (a)–(c) (). Data are expressed as % of noninsulted/untreated control. Figure symbol is , < 0.01, compared with noninsult/untreated control group by one-factor ANOVA followed with Tukey HSD test.
(a)
(b)
(c)
(d)
(e)
(f)