Oxidative Medicine and Cellular Longevity / 2016 / Article / Tab 2

Research Article

Glutathione as a Biomarker in Parkinson’s Disease: Associations with Aging and Disease Severity

Table 2

Measures of brain, blood, and urine redox status in individuals with Parkinson’s disease.

CNS uptakePhase 2b baselineCombined

Brain Glu concentrations
 MRS Glu : creatine ratio (putamen) ()0.026 (.018).030 (.017).028 (.017)
Whole blood
 Total GSH (micromol/L) ()1027.64 (279.15)1076.02 (311.85)1063.71 (302.08)
 RBC % GSSG 0.96%
Serum
 Sulfate (mg/dL) ()3.83 (.62)3.60 (.70)3.66 (.69)
 Cysteine (mg/dL) ().69 (.12).70 (.11).70 (.11)
 Cystine (mg/dL) ()2.78 (.34)2.66 (.43)2.69 (.41)
 Lipid peroxides (micromol/L)6.95 (2.49)6.52 (1.87)6.63 (2.03)
 Total antioxidant capacity (mmol/L)0.78 (0.07)0.75 (0.084)0.76 (0.08)
Urine
 Lipid peroxides (micromol/g cre)8.43 (1.92)8.14 (2.34)8.22 (2.22)
 8-OHdG (mcg/g creatinine) ()9.86 (1.99)9.92 (9.99)9.91 (8.60)
Enzyme activity, whole blood
 Glu peroxidase (GPX) (U/g Hb) 34.64 (7.94)31.55 (6.80)32.34 (7.16)
 Superoxide dismutase (U/g Hb)11189 (4463)14622 (4189)13748 (4481)

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