Antipsychotic Treatment Reduces Indices of Oxidative Stress in First-Episode Psychosis Patients

Table 1

Comparisons of oxidative stress markers (OxS) between the first-episode psychosis patients at baseline (FEP) and control subjects (CS) as well as FEP patients at baseline (FEP) and after 7 months of treatment (FEP) with antipsychotics.

OxS markers	CS	FEP	FEP	-value	value	-value	value
	Median (min–max)	Median (min–max)	Median (min–max)
TAC	1.43 (0.92–2.08)	1.42 (0.79–2.19)	1.47 (1.06–2.43)		0.25	1.56	0.12
TPX	332.50 (101.00–737.00)	380.00 (166.76–1357.53)	289.00 (88.00–915.55)	1.03	0.30	2.20	0.03
OSI	21.87 (6.16–53.80)	24.38 (11.36–92.02)	19.34 (6.03–67.82)	1.32	0.19	2.56	0.01
Met	9.08 (4.43–35.20)	7.75 (4.46–26.30)	12.50 (4.53–33.50)	0.80	0.43	2.50	0.01
Met-SO	10.80 (3.04–23.10)	10.35 (2.11–24.90)	8.72 (1.69–20.30)		0.33	2.05	0.04
Met-SO/Met	1.44 (0.16–4.29)	1.35 (0.11–4.39)	0.66 (0.05–3.54)		0.39	2.15	0.03

-adjusted values according to Mann-Whitney test (FEP compared to CS).
-values according to Wilcoxon matched pairs test (FEP compared to FEP).
TAC: total antioxidant capacity; TPX: total level of peroxides; OSI: oxidative stress index; Met: methionine; Met-SO: methionine sulfoxide; Met-SO/Met: ratio of oxidized methionine to methionine.