Antipsychotic Treatment Reduces Indices of Oxidative Stress in First-Episode Psychosis Patients

Table 3

Regression coefficients () and significance values of log₁₀-transformed oxidative stress (OxS) markers’ levels in first-episode patients’ group before treatment compared to log₁₀-transformed markers’ values measured after 7 months of treatment with antipsychotics.

Biomarkers		(95% CI)	t-value	p value
OxS markers
TAC		−0.42–0.05		0.12
TPX		0.02–0.48		0.04
OSI		0.07–0.53		0.01
Met		−0.43–0.05		0.11
Met-SO	0.15	−0.10–0.38	1.21	0.23
Met-SO/Met	0.18	−0.06–0.42	1.51	0.14

CI: confidence intervals; TAC: total antioxidant capacity; TPX: total level of peroxides; OSI: oxidative stress index; Met: methionine; Met-SO: methionine sulfoxide; Met-SO/Met: ratio of oxidized methionine to methionine.