Resveratrol: A Potential Hippocampal Plasticity Enhancer

Figure 1

Adult hippocampal neurogenesis markers. AHN is a highly regulated process that occurs in stages. In this sense, the pool of NPCs expressing markers such as GFAP and nestin is under constant self-renewal through regulated proliferative activity. Proliferation can be assessed by the number of cells expressing the cell division markers Ki-67 and BrdU (in this case, when the tissue is fixed 24 h following the last injection of BrdU). Next, the cells undergo the stage of fate specification when they express PSA-NCAM and DCX, if given the specific molecular signaling to commit into a neuronal lineage. After this stage of fate commitment, the newborn neurons undergo maturation and express the neuronal markers NeuN and calbindin. AHN = adult hippocampal neurogenesis; BrdU = bromodeoxyuridine; DCX = doublecortin; GFAP = glial fibrillary acidic protein; NeuN = neuronal nuclei; NPCs = neural progenitor cells; and PSA-NCAM = polysialylated neuronal cell adhesion molecule.