Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 9734816, 9 pages
http://dx.doi.org/10.1155/2016/9734816
Review Article

Overview of the Role of Vanillin on Redox Status and Cancer Development

1Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ-BA), Salvador, BA, Brazil
2Department of Pharmaceutical Sciences, Universidade Federal da Paraíba, 58051-970 João Pessoa, PB, Brazil

Received 17 September 2016; Revised 4 November 2016; Accepted 21 November 2016

Academic Editor: Kum Kum Khanna

Copyright © 2016 Daniel Pereira Bezerra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Waris and H. Ahsan, “Reactive oxygen species: role in the development of cancer and various chronic conditions,” Journal of Carcinogenesis, vol. 5, article 14, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. M. V. Sobral, A. L. Xavier, T. C. Lima, and D. P. De Sousa, “Antitumor activity of monoterpenes found in essential oils,” The Scientific World Journal, vol. 2014, Article ID 953451, 35 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. A. A. Carvalho, L. N. Andrade, É. B. V. de Sousa, and D. P. de Sousa, “Antitumor phenylpropanoids found in essential oils,” BioMed Research International, vol. 2015, Article ID 392674, 21 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. L. N. Andrade, T. C. Lima, R. G. Amaral et al., “Evaluation of the cytotoxicity of structurally correlated p-menthane derivatives,” Molecules, vol. 20, no. 7, pp. 13264–13280, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. D. P. de Sousa, Bioactive Essential Oils and Cancer, Springer International, New York, NY, USA, 1st edition, 2015.
  6. V. Georgiev, A. Ananga, and V. Tsolova, “Recent advances and uses of grape flavonoids as nutraceuticals,” Nutrients, vol. 6, no. 1, pp. 391–415, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Kandaswami, L. T. Lee, P. P. Lee et al., “The antitumor activities of flavonoids,” In Vivo, vol. 19, pp. 895–909, 2005. View at Google Scholar
  8. H. Priefert, J. Rabenhorst, and A. Steinbüchel, “Biotechnological production of vanillin,” Applied Microbiology and Biotechnology, vol. 56, no. 3-4, pp. 296–314, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. G. S. Clark, “Vanillin: perfume,” Flavour, vol. 15, pp. 45–54, 1990. View at Google Scholar
  10. N. A. Zamzuri and S. Abd-Aziz, “Biovanillin from agro wastes as an alternative food flavour,” Journal of the Science of Food and Agriculture, vol. 93, no. 3, pp. 429–438, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. L. S. Pedroso, G. M. Fávero, L. E. A. De Camargo, R. M. Mainardes, and N. M. Khalil, “Effect of the o-methyl catechols apocynin, curcumin and vanillin on the cytotoxicity activity of tamoxifen,” Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 28, no. 4, pp. 734–740, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Tai, T. Sawano, F. Yazama, and H. Ito, “Evaluation of antioxidant activity of vanillin by using multiple antioxidant assays,” Biochimica et Biophysica Acta—General Subjects, vol. 1810, no. 2, pp. 170–177, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Sawa, M. Nakao, T. Akaike, K. Ono, and H. Maeda, “Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: implications for the anti-tumor-promoter effect of vegetables,” Journal of Agricultural and Food Chemistry, vol. 47, no. 2, pp. 397–402, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. B. N. Ames and M. K. Shigenaga, “DNA damage by endogenous oxidants and mitogenesis as causes of aging and cancer,” in Molecular Biology of Free Radical Scavengers System, J. G. Scandalios, Ed., pp. 1–22, Cold Spring Harbor Laboratory Press, Plain-View, NY, USA, 1993. View at Google Scholar
  15. B. N. Ames and L. S. Gold, “Chemical carcinogenesis: too many rodent carcinogens,” Proceedings of the National Academy of Sciences of the United States of America, vol. 87, no. 19, pp. 7772–7776, 1990. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Ahmad, Oxidative Stress and Antioxidant Defenses in Biology, Chapman & Hall, New York, NY, USA, 1995.
  17. Z. Yan-Chun and Z. Rong-Liang, “Phenolic compounds and an analog as superoxide anion scavengers and anti oxidants,” Biochemical Pharmacology, vol. 42, no. 6, pp. 1177–1179, 1991. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Deters, H. Knochenwefel, D. Lindhorst et al., “Different curcuminoids inhibit T-lymphocyte proliferation independently of their radical scavenging activities,” Pharmaceutical Research, vol. 25, no. 8, pp. 1822–1827, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. B. N. Shyamala, M. Madhava Naidu, G. Sulochanamma, and P. Srinivas, “Studies on the antioxidant activities of natural vanilla extract and its constituent compounds through in vitro models,” Journal of Agricultural and Food Chemistry, vol. 55, no. 19, pp. 7738–7743, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Rosa, M. Deiana, G. Corona et al., “Protective effect of capsinoid on lipid peroxidation in rat tissues induced by Fe-NTA,” Free Radical Research, vol. 39, no. 11, pp. 1155–1162, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. J. P. Kamat, A. Ghosh, and T. P. A. Devasagayam, “Vanillin as an antioxidant in rat liver mitochondria: inhibition of protein oxidation and lipid peroxidation induced by photosensitization,” Molecular and Cellular Biochemistry, vol. 209, no. 1-2, pp. 47–53, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Harish, S. Divakar, A. Srivastava, and T. Shivanandappa, “Isolation of antioxidant compounds from the methanolic extract of the roots of Decalepis hamiltonii (Wight and Arn.),” Journal of Agricultural and Food Chemistry, vol. 53, no. 20, pp. 7709–7714, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. D. K. Maurya, S. Adhikari, C. K. K. Nair, and T. P. A. Devasagayam, “DNA protective properties of vanillin against γ-radiation under different conditions: possible mechanisms,” Mutation Research, vol. 634, no. 1-2, pp. 69–80, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Dhanalakshmi, T. Manivasagam, J. Nataraj, A. J. Thenmozhi, and M. M. Essa, “Neurosupportive role of vanillin, a natural phenolic compound, on rotenone induced neurotoxicity in SH-SY5Y neuroblastoma cells,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 626028, 11 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Makni, Y. Chtourou, H. Fetoui, E. M. Garoui, T. Boudawara, and N. Zeghal, “Evaluation of the antioxidant, anti-inflammatory and hepatoprotective properties of vanillin in carbon tetrachloride-treated rats,” European Journal of Pharmacology, vol. 668, no. 1-2, pp. 133–139, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Ben Saad, D. Driss, S. Ellouz Chaabouni et al., “Vanillin mitigates potassium bromate-induced molecular, biochemical and histopathological changes in the kidney of adult mice,” Chemico-Biological Interactions, vol. 252, pp. 102–113, 2016. View at Publisher · View at Google Scholar
  27. L. R. G. Castor, K. A. Locatelli, and V. F. Ximenes, “Pro-oxidant activity of apocynin radical,” Free Radical Biology and Medicine, vol. 48, no. 12, pp. 1636–1643, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. K. C. Machado, G. L. S. Oliveira, É. B. V. de Sousa et al., “Spectroscopic studies on the in vitro antioxidant capacity of isopentyl ferulate,” Chemico-Biological Interactions, vol. 225, pp. 47–53, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. B. Dimitrios, “Sources of natural phenolic antioxidants,” Trends in Food Science and Technology, vol. 17, no. 9, pp. 505–512, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Harish, S. Divakar, A. Srivastava, and T. Shivanandappa, “Isolation of antioxidant compounds from the methanolic extract of the roots of Decalepis hamiltonii (Wight and Arn.),” Journal of Agricultural and Food Chemistry, vol. 53, no. 20, pp. 7709–7714, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Kada and K. Shimoi, “Desmutagens and bio-antimutagens—their modes of action,” BioEssays, vol. 7, no. 3, pp. 113–116, 1987. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Ohta, M. Watanabe, K. Watanabe, Y. Shirasu, and T. Kada, “Inhibitory effects of flavourings on mutagenesis induced by chemicals in bacteria,” Food and Chemical Toxicology, vol. 24, no. 1, pp. 51–54, 1986. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Ohta, M. Watanabe, Y. Shirasu, and T. Inoue, “Post-replication repair and recombination in uvrAumuC strains of Escherichia coli are enhanced by vanillin, an antimutagenic compound,” Mutation Research, vol. 201, no. 1, pp. 107–112, 1988. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Takahashi, M. Sekiguchi, and Y. Kawazoe, “Effects of vanillin and o-vanillin on induction of DNA-repair networks: modulation of mutagenesis in Escherichia coli,” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 230, no. 2, pp. 127–134, 1990. View at Publisher · View at Google Scholar · View at Scopus
  35. D. T. Shaughnessy, R. W. Setzer, and D. M. DeMarini, “The antimutagenic effect of vanillin and cinnamaldehyde on spontaneous mutation in Salmonella TA104 is due to a reduction in mutations at GC but not AT sites,” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 480-481, pp. 55–69, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. S. De Flora, C. Bennicelli, A. Rovida, L. Scatolini, and A. Camoirano, “Inhibition of the ‘spontaneous’ mutagenicity in Salmonella typhimurium TA102 and TA104,” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 307, no. 1, pp. 157–167, 1994. View at Publisher · View at Google Scholar · View at Scopus
  37. D. T. Shaughnessy, R. M. Schaaper, D. M. Umbach, and D. M. DeMarini, “Inhibition of spontaneous mutagenesis by vanillin and cinnamaldehyde in Escherichia coli: dependence on recombinational repair,” Mutation Research, vol. 602, no. 1-2, pp. 54–64, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. H. H. R. de Andrade, J. H. Santos, M. C. Gimmler-Luz, M. J. F. Correa, M. Lehmann, and M. L. Reguly, “Suppressing effect of vanillin on chromosome aberrations that occur spontaneously or are induced by mitomycin C in the germ cell line of Drosophila melanogaster,” Mutation Research, vol. 279, no. 4, pp. 281–287, 1992. View at Publisher · View at Google Scholar · View at Scopus
  39. J. H. Santos, U. Graf, M. L. Reguly, and H. H. Rodrigues De Andrade, “The synergistic effects of vanillin on recombination predominate over its antimutagenic action in relation to MMC-induced lesions in somatic cells of Drosophila melanogaster,” Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 444, no. 2, pp. 355–365, 1999. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Sinigaglia, M. L. Reguly, and H. H. Rodrigues De Andrade, “Effect of vanillin on toxicant-induced mutation and mitotic recombination in proliferating somatic cells of Drosophila melanogaster,” Environmental and Molecular Mutagenesis, vol. 44, no. 5, pp. 394–400, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Sinigaglia, M. Lehmann, P. Baumgardt et al., “Vanillin as a modulator agent in SMART test: inhibition in the steps that precede N-methyl-N-nitrosourea-, N-ethyl-N-nitrosourea-, ethylmethanesulphonate- and bleomycin-genotoxicity,” Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 607, no. 2, pp. 225–230, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. M. P. Furlanetto, M. Sinigaglia, V. S. Do Amaral, R. R. Dihl, and H. H. R. De Andrade, “Effect of vanillin on toxicant-induced lethality in the Drosophila melanogaster DNA repair test,” Environmental and Molecular Mutagenesis, vol. 48, no. 1, pp. 67–70, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. Y. F. Sasaki, H. Imanishi, T. Ohta, and Y. Shirasu, “Effects of antimutagenic flavourings on SCEs induced by chemical mutagens in cultured Chinese hamster cells,” Mutation Research/Genetic Toxicology, vol. 189, no. 3, pp. 313–318, 1987. View at Google Scholar · View at Scopus
  44. Y. Sasaki, H. Imanishi, T. Ohta, and Y. Shirasu, “Effects of vanillin on sister-chromatid exchanges and chromosome aberrations induced by mitomycin C in cultured Chinese hamster ovary cells,” Mutation Research Letters, vol. 191, no. 3-4, pp. 193–200, 1987. View at Publisher · View at Google Scholar · View at Scopus
  45. Y. Sasaki, H. Imanishi, M. Watanabe, T. Ohta, and Y. Shirasu, “Suppressing effect of antimutagenic flavorings on chromosome aberrations induced by UV-light or X-rays in cultured Chinese hamster cells,” Mutation Research, vol. 229, no. 1, pp. 1–10, 1990. View at Publisher · View at Google Scholar · View at Scopus
  46. H. Imanishi, Y. Sasaki, K. Matsumoto et al., “Suppression of 6-TG-resistant mutations in V79 cells and recessive spot formations in mice by vanillin,” Mutation Research Letters, vol. 243, no. 2, pp. 151–158, 1990. View at Publisher · View at Google Scholar · View at Scopus
  47. K. Tamai, H. Tezuka, and Y. Kuroda, “Different modifications by vanillin in cytotoxicity and genetic changes induced by EMS and H2O2 in cultured Chinese hamster cells,” Mutation Research, vol. 268, no. 2, pp. 231–237, 1992. View at Publisher · View at Google Scholar · View at Scopus
  48. C. Keshava, N. Keshava, W. Z. Whong, J. Nath, and T. M. Ong, “Inhibition of methotrexate-induced chromosomal damage by vanillin and chlorophyllin in V79 cells,” Teratogenesis, Carcinogenesis and Mutagenesis, vol. 17, pp. 313–326, 1997-1998. View at Google Scholar
  49. C. Keshava, N. Keshava, T.-M. Ong, and J. Nath, “Protective effect of vanillin on radiation-induced micronuclei and chromosomal aberrations in V79 cells,” Mutation Research, vol. 397, no. 2, pp. 149–159, 1998. View at Publisher · View at Google Scholar · View at Scopus
  50. T. Inouye, Y. F. Sasaki, H. Imanishi, M. Watanabe, T. Ohta, and Y. Shirasu, “Suppression of mitomycin C-induced micronuclei in mouse bone marrow cells by post-treatment with vanillin,” Mutation Research, vol. 202, no. 1, pp. 93–95, 1988. View at Publisher · View at Google Scholar · View at Scopus
  51. Y. Sasaki, T. Ohta, H. Imanishi et al., “Suppressing effects of vanillin, cinnamaldehyde, and anisaldehyde on chromosome aberrations induced by X-rays in mice,” Mutation Research Letters, vol. 243, no. 4, pp. 299–302, 1990. View at Publisher · View at Google Scholar · View at Scopus
  52. S. S. Kumar, A. Ghosh, T. P. A. Devasagayam, and P. S. Chauhan, “Effect of vanillin on methylene blue plus light-induced single-strand breaks in plasmid pBR322 DNA,” Mutation Research, vol. 469, no. 2, pp. 207–214, 2000. View at Publisher · View at Google Scholar · View at Scopus
  53. D. L. Gustafson, H. R. Franz, A. M. Ueno, C. J. Smith, D. J. Doolittle, and C. A. Waldren, “Vanillin (3-methoxy-4-hydroxybenzaldehyde) inhibits mutation induced by hydrogen peroxide, N-methyl-N-nitrosoguanidine and mitomycin C but not 137Cs-γ-radiation at the CD59 locus in human-hamster hybrid AL cells,” Mutagenesis, vol. 15, no. 3, pp. 207–213, 2000. View at Publisher · View at Google Scholar · View at Scopus
  54. S. Durant and P. Karran, “Vanillins—a novel family of DNA-PK inhibitors,” Nucleic Acids Research, vol. 31, no. 19, pp. 5501–5512, 2003. View at Publisher · View at Google Scholar · View at Scopus
  55. R. Sanyal, F. Darroudi, W. Parzefall, M. Nagao, and S. Knasmüller, “Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens,” Mutagenesis, vol. 12, no. 4, pp. 297–303, 1997. View at Publisher · View at Google Scholar · View at Scopus
  56. A. A. King, D. T. Shaughnessy, K. Mure et al., “Antimutagenicity of cinnamaldehyde and vanillin in human cells: global gene expression and possible role of DNA damage and repair,” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 616, no. 1-2, pp. 60–69, 2007. View at Publisher · View at Google Scholar · View at Scopus
  57. J. Lee, J. Y. Cho, S. Y. Lee, K.-W. Lee, J. Lee, and J.-Y. Song, “Vanillin protects human keratinocyte stem cells against Ultraviolet B irradiation,” Food and Chemical Toxicology, vol. 63, pp. 30–37, 2014. View at Publisher · View at Google Scholar · View at Scopus
  58. H. Ben Saad, I. Ben Amara, N. Krayem et al., “Ameliorative effects of vanillin on potassium bromate induces bone and blood disorders in vivo,” Cellular and Molecular Biology, vol. 61, pp. 12–22, 2015. View at Google Scholar
  59. H. Ben Saad, D. Driss, I. Ben Amara et al., “Altered hepatic mRNA expression of immune response-associated DNA damage in mice liver induced by potassium bromate: protective role of vanillin,” Environmental Toxicology, vol. 31, no. 12, pp. 1796–1807, 2016. View at Publisher · View at Google Scholar · View at Scopus
  60. H. Tsuda, N. Uehara, Y. Iwahori et al., “Chemopreventive effects of β-carotene, α-tocopherol and five naturally occurring antioxidants on initiation of hepatocarcinogenesis by 2-amino-3-methylimidazo[4,5-f]quinoline in the rat,” Japanese Journal of Cancer Research, vol. 85, no. 12, pp. 1214–1219, 1994. View at Publisher · View at Google Scholar · View at Scopus
  61. K. Akagi, M. Hirose, T. Hoshiya, Y. Mizoguchi, N. Ito, and T. Shirai, “Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model,” Cancer Letters, vol. 94, no. 1, pp. 113–121, 1995. View at Publisher · View at Google Scholar · View at Scopus
  62. K. L. Ho, P. P. Chong, L. S. Yazan, and M. Ismail, “Vanillin differentially affects azoxymethane-injected rat colon carcinogenesis and gene expression,” Journal of Medicinal Food, vol. 15, no. 12, pp. 1096–1102, 2012. View at Publisher · View at Google Scholar · View at Scopus
  63. S. Kapoor, “Multiorgan anticarcinogenic effects of vanillin,” Journal of Medicinal Food, vol. 16, no. 9, pp. 777–777, 2013. View at Publisher · View at Google Scholar · View at Scopus
  64. K. Lirdprapamongkol, H. Sakurai, N. Kawasaki et al., “Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells,” European Journal of Pharmaceutical Sciences, vol. 25, no. 1, pp. 57–65, 2005. View at Publisher · View at Google Scholar · View at Scopus
  65. J.-A. Liang, S.-L. Wu, H.-Y. Lo, C.-Y. Hsiang, and T.-Y. Ho, “Vanillin inhibits matrix metalloproteinase-9 expression through down-regulation of nuclear factor-κB signaling pathway in human hepatocellular carcinoma cells,” Molecular Pharmacology, vol. 75, no. 1, pp. 151–157, 2009. View at Publisher · View at Google Scholar · View at Scopus
  66. K. Lirdprapamongkol, J.-P. Kramb, T. Suthiphongchai et al., “Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in vivo,” Journal of Agricultural and Food Chemistry, vol. 57, no. 8, pp. 3055–3063, 2009. View at Publisher · View at Google Scholar · View at Scopus
  67. H. Babich, E. Borenfreund, and A. Stern, “Comparative cytotoxicities of selected minor dietary non-nutrients with chemopreventive properties,” Cancer Letters, vol. 73, no. 2-3, pp. 127–133, 1993. View at Publisher · View at Google Scholar · View at Scopus
  68. K. Ho, L. S. Yazan, N. Ismail, and M. Ismail, “Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin,” Cancer Epidemiology, vol. 33, no. 2, pp. 155–160, 2009. View at Publisher · View at Google Scholar · View at Scopus
  69. W.-Y. Cheng, C.-Y. Hsiang, D.-T. Bau et al., “Microarray analysis of vanillin-regulated gene expression profile in human hepatocarcinoma cells,” Pharmacological Research, vol. 56, no. 6, pp. 474–482, 2007. View at Publisher · View at Google Scholar · View at Scopus
  70. K. Lirdprapamongkol, H. Sakurai, S. Suzuki et al., “Vanillin enhances TRAIL-induced apoptosis in cancer cells through inhibition of NF-kappaB activation,” In Vivo, vol. 24, no. 4, pp. 501–506, 2010. View at Google Scholar · View at Scopus
  71. J. Deb, H. Dibra, S. Shan et al., “Activity of aspirin analogues and vanillin in a human colorectal cancer cell line,” Oncology Reports, vol. 26, no. 3, pp. 557–565, 2011. View at Publisher · View at Google Scholar · View at Scopus