Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo

Figure 10

Nano-CT and SEM-EDX analysis. Nano-CT images of tibia bones and their transverse sections from control (I, II) and Met 8 (III, IV) mouse. White arrows indicate direction of performed scanning. Quantification of cortical bone density (b) and medullary cavity volume (c) in mice tibias by Nano-CT. SEM-EDX assessment of calcium (d) and phosphorus (e) content in tibia from control and Met 8 group. Mean bone porosity assessed by Nano-CT in the studied groups (f). Results expressed as mean, .

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