Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells <i>In Vitro</i>, and Increases Bone Density <i>In Vivo</i>

<div>Morphology and cellular composition of MuASCs evaluated on 7th day of culture; light microscope (a, f), staining for DAPI (b, g), DAPI/phalloidin merged (c, h), and SEM (d, e, i, j) images. Morphological features were indicated with proper abbreviations: fp: filopodia, lp: lamellipodia, and mvs: microvesicles. Magnification: DAPI ×50, scale bar: 250 <i>μ</i>m; DAPI/phalloidin ×100, scale bar: 250 <i>μ</i>m; SEM ×5000, scale bar 2 <i>μ</i>m.</div>

Oxidative Medicine and Cellular Longevity

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Figure 4: Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells <i>In Vitro</i>, and Increases Bone Density <i>In Vivo</i> 

Figure 4 | Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo 