Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation

Figure 2

Ebselen treatment prevented the CB chemosensory potentiation in rats exposed to CIH. (a) Recordings of the CB frequency of chemosensory discharge () measured from the carotid sinus nerve in response to acute hypoxia (5% O₂) in rats treated with Ebselen or vehicle and exposed to sham or CIH conditions. The enhanced CB chemosensory response induced by CIH (vehicle CIH) was prevented by Ebselen (Ebselen CIH). (b) Summary of the effect of the Ebselen treatment at different levels of inspired PO₂ (mmHg) on . , vehicle CIH versus Ebselen sham and Ebselen CIH, and Bonferroni after two-way ANOVA, rats per group.

(a)

(b)